Climara Pro

(estradiol / levonorgestrel patch)

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Relieves hot flashes and lowers your risk of osteoporosis.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

The Climara Pro (estradiol / levonorgestrel patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combination medications but prefer to use a patch once a week instead of pills every day.

Lowest price near you
  • Lowest price with coupon
    $208.37
Quick facts about Climara Pro
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Once-a-week patch. Good for people who don't want to take daily pills.
  • Replaces estrogen in your body and relieves multiple symptoms from low estrogen, such as hot flashes and vaginal dryness.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Good for women with an intact uterus. The progestin in the patch protects against the risk of cancer in the uterus.
  • The Climara Pro (estradiol / levonorgestrel patch) patch has a lower risk of causing blood clots and stroke compared to other forms containing the same medicines.
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What to expect from Climara Pro, on one page

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Downsides

  • More potential side effects than medications with one ingredient since Climara Pro (estradiol / levonorgestrel patch) exposes your whole body to two hormones.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can fall off, especially if you like to regularly swim, take baths, or use saunas.
  • Can be expensive since it's only available as a brand name product.
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What to expect from Climara Pro, on one page

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How it works

Climara Pro (estradiol / levonorgestrel patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estrogen reduces hot flashes, reduces night sweats, and prevents bone loss. Progestin protects the uterus from damage.

Quick facts about Climara Pro
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Hot flashes and night sweats
  • Prevention of postmenopausal osteoporosis

Dosage forms

  • Patch
Tried Climara Pro? Write a review!

Prices and coupons

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What to expect when you take Climara Pro (estradiol / levonorgestrel patch) for Menopause symptoms

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Skin irritation
  • Vaginal bleeding
  • Breast pain
  • Back pain
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Side effect rates for Climara Pro (estradiol / levonorgestrel patch)

From 212 clinical trials of Climara Pro when taken for postmenopausal hormone replacement (0.045/0.015 mg)
  • Skin irritation
    41%41%
  • Vaginal bleeding
    37%37%
  • Breast pain
    19%19%
  • Lung infection
    13%13%
  • Back pain
    6%6%
  • Depression
    6%6%
  • Flu like symptoms
    5%5%
  • Pain
    5%5%
  • Headache
    5%5%
  • Stomach pain
    4%4%
  • Gas
    4%4%
  • Swelling of arms and legs
    4%4%
  • Joint pain
    4%4%
  • Airway inflammation
    4%4%
  • Sinus infection
    4%4%
  • Accidental injury
    3%3%
  • Infection
    3%3%
  • High blood pressure
    3%3%
  • Weight gain
    3%3%
  • Bladder infection
    3%3%
  • Rash
    2%2%
  • Vaginal inflammation
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Climara Pro.

Climara Pro (estradiol / levonorgestrel patch)
Placebo

People taking Climara Pro felt side effect more

People taking Climara Pro felt side effect less

No difference

Risks and Warnings for Climara Pro (estradiol / levonorgestrel patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    If you're taking Climara Pro (estradiol / levonorgestrel patch) and have your uterus, you might have a higher risk of having endometrial cancer. Vaginal bleeding after menopause can be a warning sign, so let your doctor know if you notice any unusual bleeding. Using medicines like Climara Pro (estradiol / levonorgestrel patch) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Climara Pro (estradiol / levonorgestrel patch) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Climara Pro (estradiol / levonorgestrel patch)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Climara Pro
XUnsafe
Weight
  • Can cause nausea, dizziness, bloating, and breast tenderness. Tell your doctor right away if you have unusual vaginal bleeding.