Tybost

(cobicistat)

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Works with other medicines to treat HIV infection.

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Our bottom line

Tybost (cobicistat) is used because it can strengthen the effect of some HIV medicines while stopping side effects, but it can't be used with all HIV medicines.

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    $226.90
Quick facts about Tybost
  • Drug class: Infection
  • Rx status:
  • Generic status: No lower cost generic available

Upsides

  • Tybost (cobicistat) is one of the first choice medications taken in combination with other HIV drugs to treat HIV. These combinations are pills you only take once a day, like Genvoya or Stribild.
  • The dose of Tybost (cobicistat) doesn't have to be adjusted if you have kidney or liver damage.
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What to expect from Tybost, on one page

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Downsides

  • Tybost (cobicistat) by itself doesn't have any activity against HIV. It must be taken with other medications to treat HIV.
  • Tybost (cobicistat) interacts with many other drugs.
  • Tybost (cobicistat) can make it harder for your doctor to check your kidneys.
  • Tybost (cobicistat) can increase your cholesterol levels.
  • Tybost (cobicistat) can only be used with two HIV medications, atazanavir and once-daily darunavir. It can't be used with other similar protease inhibitors.
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What to expect from Tybost, on one page

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How it works

Tybost (cobicistat) strengthens the effect of other HIV medicines called protease inhibitors by stopping the liver from breaking them down too quickly, but it doesn't treat HIV by itself.

Quick facts about Tybost
  • Drug class: Infection
  • Rx status:
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Tybost? Write a review!

Prices and coupons

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What to expect when you take Tybost (cobicistat) for HIV treatment

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Jaundice
  • Rash
  • Nausea
  • Diarrhea
  • Headache
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Side effect rates for Tybost (cobicistat)

From 344 clinical trials of Tybost when taken for hiv infection treatment (taken with atazanavir + truvada)
  • Jaundice
    6%6%
  • Rash
    5%5%
  • Yellowing of eyes
    4%4%
  • Nausea
    2%2%
  • Diarrhea
    2%2%
  • Headache
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Tybost.

Tybost (cobicistat)
Placebo

People taking Tybost felt side effect more

People taking Tybost felt side effect less

No difference

Risks and Warnings for Tybost (cobicistat)

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    • Higher risk if:
    • HIV
    • Exposure to other infections
    • Start of a new HIV medication
    • Change in HIV therapy

    Taking Tybost (cobicistat) can strengthen your immune system's response to infections that were hiding when your body was too weak to defend itself. Call your doctor if you experience fever, difficulty breathing, or sudden changes to your health.

Common concerns from people taking Tybost (cobicistat)

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Interactions
  • Tybost (cobicistat) is known to interact with many other drugs. This can lead to serious or life-threatening side effects. Talk to your doctor or pharmacist before starting or stopping medications. They can help you find the best combinations to avoid harmful drug interactions.
  • Tybost (cobicistat) interacts with many other drugs.
Food
  • Take Tybost (cobicistat) with food and at the same time as the drug it is boosting (Reyataz or Prezista).
Kidneys and liver
  • Tybost (cobicistat) can cause changes to blood tests for the kidney or kidney damage, especially if you're taking tenofovir as part of your HIV medicines. If you already have kidney damage, this might mean your doctor will change the doses of your other medicines, or you may not be able to use Tybost (cobicistat). Talk to your doctor if this is a problem.
  • The dose of Tybost (cobicistat) doesn't have to be adjusted if you have kidney or liver damage.