Combipatch

(estradiol / norethindrone patch)

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Treats low estrogen and relieves menopause symptoms.

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Our bottom line

Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.

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    $181.68
Quick facts about Combipatch
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
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What to expect from Combipatch, on one page

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Downsides

  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
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What to expect from Combipatch, on one page

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How it works

Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.

Quick facts about Combipatch
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Hot flashes
  • Vaginal dryness and inflammation
  • Low estrogen

Dosage forms

  • Patch
Tried Combipatch? Write a review!

Prices and coupons

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What to expect when you take Combipatch (estradiol / norethindrone patch) for Postmenopausal hormone replacement

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Breast pain
  • Vaginal inflammation
  • Weakness
  • Headache
  • Back pain
  • Menstrual cramps
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Side effect rates for Combipatch (estradiol / norethindrone patch)

From 220 clinical trials of Combipatch when taken for postmenopausal hormone replacement (0.05/0.14 mg)
  • Breast pain
    25%25%
    7%7%
  • Menstrual cramps
    20%20%
    5%5%
  • Headache
    18%18%
    20%20%
  • Back pain
    11%11%
    5%5%
  • Nausea
    11%11%
    7%7%
  • Flu like symptoms
    9%9%
    7%7%
  • Weakness
    8%8%
    4%4%
  • Abnormal pap smear
    8%8%
    5%5%
  • Stomach pain
    7%7%
    4%4%
  • Lung problems
    7%7%
    7%7%
  • Stuffy nose
    7%7%
    9%9%
  • Pain
    6%6%
    9%9%
  • Menstrual problems
    6%6%
    2%2%
  • Vaginal inflammation
    6%6%
    5%5%
  • Vaginal discharge
    5%5%
    3%3%
  • Accidental injury
    4%4%
    8%8%
  • Diarrhea
    4%4%
    7%7%
  • Gas
    4%4%
    4%4%
  • Sore throat
    4%4%
    2%2%
  • Sinus infection
    4%4%
    9%9%
  • Depression
    3%3%
    9%9%
  • Trouble sleeping
    3%3%
    7%7%
  • Nervousness
    3%3%
    1%1%
  • Skin irritation
    2%2%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Combipatch.

Combipatch (estradiol / norethindrone patch)
Placebo

People taking Combipatch felt side effect more

People taking Combipatch felt side effect less

No difference

Risks and Warnings for Combipatch (estradiol / norethindrone patch)

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    • Higher risk if:
    • Using estrogen for more than one year

    If you're taking Combipatch (estradiol / norethindrone patch) and have an intact uterus, you might have a higher risk of endometrial cancer. Vaginal bleeding after menopause can be a warning sign, so let your doctor know if you notice any unusual bleeding. Using medicines like Combipatch (estradiol / norethindrone patch) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Combipatch (estradiol / norethindrone patch) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect