Comtan

(entacapone)

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Treats Parkinson's disease.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Comtan (entacapone) enhances the effect of carbidopa/levodopa. It's usually added on when carbidopa/levodopa starts to lose its effect on Parkinson's disease.

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    $2742.68
Quick facts about entacapone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (entacapone)

Upsides

  • Allows you to get more out of carbidopa/levodopa, especially in later stages of Parkinson's disease.
  • Comtan (entacapone) is available in a single pill combination with carbidopa/levodopa.
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Downsides

  • Must be taken with other medicines for Parkinson's disease
  • Can make you lightheaded especially if you suddenly stand up from sitting or lying down.
  • Can make you very sleepy
  • May require frequent adjustments before finding the dose that works best for you
How it works

Comtan (entacapone) is a COMT inhibitor. It prevents levodopa from breaking down before it enters the brain.

Quick facts about entacapone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (entacapone)

Dosage forms

  • Pill
Tried entacapone? Write a review!

Prices and coupons

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Side effect rates for Comtan (entacapone)

From 1003 clinical trials of entacapone when taken for parkinson's disease
  • Difficulty controlling movements
    25%25%
    15%15%
  • Nausea
    14%14%
    8%8%
  • Muscle spasm
    10%10%
    5%5%
  • Changes in urine color
    10%10%
  • Diarrhea
    10%10%
    4%4%
  • Muscle rigidity
    9%9%
    8%8%
  • Dizziness
    8%8%
    6%6%
  • Abdominal pain
    8%8%
    4%4%
  • Fatigue
    6%6%
    4%4%
  • Constipation
    6%6%
    4%4%
  • Vomiting
    4%4%
    1%1%
  • Dry mouth
    3%3%
  • Shortness of breath
    3%3%
    1%1%
  • Purple spots on the skin
    3%3%
    1%1%
  • Increased sweating
    2%2%
    1%1%
  • Back pain
    2%2%
    1%1%
  • Anxiety
    2%2%
    1%1%
  • Sleepiness
    2%2%
  • Indigestion
    2%2%
    1%1%
  • Flatulence
    2%2%
  • Weakness
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of entacapone.

Comtan (entacapone)
Placebo

People taking entacapone felt side effect more

People taking entacapone felt side effect less

No difference

Risks and Warnings for Comtan (entacapone)

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    • Higher risk if:
    • Taking other medicines for Parkinson's

    Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.

Common concerns from people taking Comtan (entacapone)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for entacapone
CWeigh risks vs. benefits
Sleep
  • Comtan (entacapone) can make you very sleepy. Don't drive or do anything that requires your full concentration until you know how Comtan (entacapone) affects you. This is more likely if you're also taking other medicines for Parkinson's. Talk to your doctor if this bothers you.
  • Can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
  • Can make you very sleepy