Dantrium

(dantrolene)

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Relaxes your muscles.

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Our bottom line

Dantrium (dantrolene) effectively treats malignant hyperthermia (increased temperature and muscle contractions when receiving anesthesia) and is the only medicine used to treat the condition. Dantrium (dantrolene) is not a first-choice treatment for general muscle spasms because it can damage your liver.

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Quick facts about Dantrium
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (dantrolene)

Upsides

  • Dantrium (dantrolene) effectively treats malignant hyperthermia.
  • Can be used for muscle spasticity if other medications haven't worked.
  • Available as generic.
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Downsides

  • Not a first-choice treatment for muscle spasms because it can cause liver damage.
  • Can cause dizziness, sleepiness, and sometimes severe diarrhea.
  • Needs routine blood tests since it can injure your liver.
  • Dose needs to be increased slowly to minimize side effects.
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How it works

Dantrium (dantrolene) stops spasms and relaxes muscle cells by interfering with the release of calcium inside muscle cells.

Quick facts about Dantrium
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (dantrolene)

Used for

  • Malignant hyperthermia
  • Chronic spasticity
  • Neuroleptic malignant syndrome

Dosage forms

  • Pill
  • Injection
Tried Dantrium? Write a review!

Prices and coupons

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What to expect when you take Dantrium (dantrolene) for Muscle spasms

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  • Effectiveness
  • Full effects
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  • Possible side effects
  • Diarrhea
  • Drowsiness
  • Dizziness
  • Weakness
  • Liver injury
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Side effect rates for Dantrium (dantrolene)

Risks and Warnings for Dantrium (dantrolene)

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    • Higher risk if:
    • Taking 800 mg or more Dantrium (dantrolene) per day
    • Women
    • Over 35 years old
    • Elderly
    • History of liver disease or dysfunction

    Dantrium (dantrolene) has been associated with liver damage, which can be serious. Although the chances of having liver injury increase with higher doses, some people have had damage taking as little as 400 mg a day. Symptoms include fever, rash, lack of appetite, abdominal pain, dark urine or yellowing of the skin and eyes. Call your doctor right away if this happens.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Dantrium (dantrolene) questions for

Frequently Asked Questions

This medication treats spasticity caused by upper motor neuron disorders, including spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.

Who is this drug for?

This medication treats spasticity caused by upper motor neuron disorders, including spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.

Common concerns from people taking Dantrium (dantrolene)

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Sleep
  • Taking Dantrium (dantrolene) may make you feel dizzy or sleepy for the first few days, especially if you drink alcohol or take recreational drugs. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Your body should adjust to the medicine. Talk to your doctor or pharmacist if these symptoms bother you.
  • Dantrium (dantrolene) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.