Depakote

(divalproex)

3.3/ 5 average rating with 97 reviewsforDepakote
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Treats and prevents seizures, and stabilizes mood.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Depakote (divalproex) is good for long-term prevention of seizures, manic episodes in bipolar disorder, and migraines.

Lowest price near you
  • Price before coupon
    $225.86
  • Lowest price with coupon
    $29.92
    87% savings
Quick facts about Depakote
  • Drug class: Neurology
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (divalproex)

Upsides

  • Lowers the frequency of seizures, especially for people with absence seizures or complex partial seizures.
  • Depakote (divalproex) is a first-line treatment to stabilize mood for people with bipolar disorder.
  • Depakote (divalproex) is helpful for preventing frequent migraines.
  • The sprinkle pill can be swallowed whole or can be opened up and mixed with applesauce if you have a hard time swallowing.
  • Depakote (divalproex) is available as a generic.
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What to expect from Depakote, on one page

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People’s experience with Depakote

97reviews so far. What do you think?

Downsides

  • It can take 3 to 4 weeks before you feel the full effects of Depakote (divalproex).
  • Depakote (divalproex) is not a good medication for people with liver problems.
  • Requires regular blood tests to see how the medication is affecting your body.
  • Depakote (divalproex) can make you bleed more easily.
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What to expect from Depakote, on one page

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How it works

Depakote (divalproex) is an antiepileptic. It increases the amount of GABA, a chemical that calms nerves in the brain.

Quick facts about Depakote
  • Drug class: Neurology
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (divalproex)

Dosage forms

  • Pill
  • Extended release pill
  • Delayed release pill
People’s experience with Depakote

97reviews so far. What do you think?

Prices and coupons

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What to expect when you take Depakote (divalproex) for Bipolar disorder

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Nausea
  • Sleepiness
  • Dizziness
  • Vomiting
  • Accidental injury
  • Feeling weak
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Depakote (divalproex)

From 186 clinical trials of Depakote when taken for bipolar disorder
  • Nausea
    22%22%
    15%15%
  • Sleepiness
    19%19%
    12%12%
  • Dizziness
    12%12%
    4%4%
  • Vomiting
    12%12%
    3%3%
  • Accidental injury
    11%11%
    5%5%
  • Feeling weak
    10%10%
    7%7%
  • Abdominal pain
    9%9%
    8%8%
  • Upset stomach
    9%9%
    8%8%
  • Rash
    6%6%
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Depakote.

Depakote (divalproex)
Placebo

People taking Depakote felt side effect more

People taking Depakote felt side effect less

No difference

Risks and Warnings for Depakote (divalproex)

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  • Depakote (divalproex) can cause harm to the unborn baby taken while you are pregnant. If you're pregnant or considering having a baby, talk to your doctor about alternative medications.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Depakote (divalproex) questions for

Frequently Asked Questions

This medication treats complex partial seizures.

Who is this drug for?

This medication treats complex partial seizures.

Common concerns from people taking Depakote (divalproex)

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Food
  • Take with food to avoid upset stomach. Do not chew, break, or crush, and swallow the pill whole.
Weight
  • Not sure
    Big hassle
    Reviewed Depakoteon 8/8/2017Weight gain, 20 lbs in a year. Half of my hair thinned out after 4 months taking it. 1 year later it's finally starting to look decent but not like it was. Tried to change some eating habits and joined a gym. And my appetite is still not the same. I'm trying to get my dr to put me on something different
    27
    Woman
    A year or so
    Bipolar II disorder
  • Not worth it
    Big hassle
    Reviewed Depakoteon 6/7/2017I gained 10 pounds every month I took depakote in odd places that I've never gained weight before. I basically became very broad (not in a good way) with a hump back. Felt like a zombie.
    29
    Woman
    A year or so
    Bipolar I disorder (manic)