Elestrin

(Estradiol gel)

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Relieves hot flashes due to menopause.

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Our bottom line

Elestrin (Estradiol gel) is a good, easy-to-use option if you don’t want to use pills or patches with estrogen hormones.

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  • Lowest price with coupon
    $209.00
Quick facts about Elestrin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Elestrin (Estradiol gel) replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Elestrin (Estradiol gel) is good for people who don't want to or can't take daily pills.
  • Elestrin (Estradiol gel) has fewer side effects than birht control pills since there are lower amounts of estrogen.
  • Most people start to feel better within 3-4 weeks of starting Elestrin (Estradiol gel).
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What to expect from Elestrin, on one page

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Downsides

  • Taking Elestrin (Estradiol gel) increases your risk for many conditions, like endometrial or breast cancer, dementia, heart disease, and blood clots.
  • You have to use Elestrin (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Not a good option for people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
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What to expect from Elestrin, on one page

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How it works

Elestrin (Estradiol gel) replaces estrogen that your body loses during menopause. Higher levels of the hormone relieve hot flashes and night sweats.

Quick facts about Elestrin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Gel
Tried Elestrin? Write a review!

Prices and coupons

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What to expect when you take Elestrin (Estradiol gel) for Hot flashes

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
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  • Possible side effects
  • Breast pain
  • Unusual vaginal bleeding
  • Common cold
  • Lung infection
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Side effect rates for Elestrin (Estradiol gel)

From 279 clinical trials of Elestrin when taken for hot flashes (1.7 g/day)
  • Unusual vaginal bleeding
    9%9%
    2%2%
  • Common cold
    9%9%
    7%7%
  • Breast pain
    8%8%
    4%4%
  • Lung infection
    4%4%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Elestrin.

Elestrin (Estradiol gel)
Placebo

People taking Elestrin felt side effect more

People taking Elestrin felt side effect less

No difference

Risks and Warnings for Elestrin (Estradiol gel)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medications like Elestrin (Estradiol gel) for more than a year can increase your risk. Talk to your doctor about other medications you can take with Elestrin (Estradiol gel) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Elestrin (Estradiol gel)

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Alcohol
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
Pain
  • Elestrin (Estradiol gel) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.