Endometrin

(progesterone vaginal insert)

3.0/ 5 average rating with 55 reviewsforEndometrin
Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Supports other fertility treatments.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.

Lowest price near you
  • Lowest price with coupon
    $242.46
Quick facts about Endometrin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Helps increase your chances of getting pregnant.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Endometrin, on one page

Download Fact Sheet
People’s experience with Endometrin

55reviews so far. What do you think?

Downsides

  • Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
  • Only available as brand name, so it may be expensive.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Endometrin, on one page

Download Fact Sheet
How it works

Endometrin (progesterone vaginal insert) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish a fertilized egg.

Quick facts about Endometrin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Vaginal insert
People’s experience with Endometrin

55reviews so far. What do you think?

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 21 (100mg) inserts of Endometrin near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Endometrin (progesterone vaginal insert) for Female infertility

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Pain after egg harvesting
  • Stomach pain
  • Nausea
  • Overstimulation of ovaries
  • Headache
  • Vomiting
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Endometrin (progesterone vaginal insert)

From 404 clinical trials of Endometrin when taken for female infertility (100 mg three times daily)
  • Pain after egg harvesting
    25%25%
  • Stomach pain
    12%12%
  • Nausea
    7%7%
  • Overstimulation of ovaries
    7%7%
  • Stomach bloating and swelling
    4%4%
  • Constipation
    3%3%
  • Fatigue
    3%3%
  • Headache
    3%3%
  • Uterine spasm
    3%3%
  • Vaginal bleeding
    3%3%
  • Vomiting
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Endometrin.

Endometrin (progesterone vaginal insert)
Placebo

People taking Endometrin felt side effect more

People taking Endometrin felt side effect less

No difference

Risks and Warnings for Endometrin (progesterone vaginal insert)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • History of heart disease
    • History of blood clots

    Endometrin (progesterone vaginal insert) should not be taken if you've had a heart attack, have heart disease, or have blood clots, since the medicine can make it worse. Tell your doctor before starting this medicine if you have a personal history of heart problems or blood clots. Go to the emergency room right away if you notice chest pain, difficulty breathing, or extreme pain in any of your limbs.