Epclusa

(velpatasvir / sofosbuvir)

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Treats hepatitis C.

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Our bottom line

Epclusa (velpatasvir / sofosbuvir) is a combination medicine that treats hepatitis C, and has been shown very effective at curing the disease in many people. It is very expensive.

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    $24754.11
Quick facts about Epclusa
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Epclusa (velpatasvir / sofosbuvir) is the first medicine approved to treat all genotypes of hepatitis C.
  • Most people only have to take one pill of Epclusa (velpatasvir / sofosbuvir) once a day for 12 weeks. If you have severe liver damage, you'll have to take it with ribavirin.
  • It can be taken with or without food.
  • The most common side effects are usually mild, including fatigue and headache.
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What to expect from Epclusa, on one page

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Downsides

  • Epclusa (velpatasvir / sofosbuvir) can only be absorbed properly in an acidic stomach so heartburn meds can affect how well it works.
  • Epclusa (velpatasvir / sofosbuvir) can cause serious drops in heart rate when it is taken with amiodarone.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.
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What to expect from Epclusa, on one page

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How it works

Epclusa (velpatasvir / sofosbuvir) is a combination of two antiviral medicines called inhibitors that stops the hepatitis C virus from making copies of itself in the body.

Quick facts about Epclusa
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
Tried Epclusa? Write a review!

Prices and coupons

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What to expect when you take Epclusa (velpatasvir / sofosbuvir) for Hepatitis C

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Headache
  • Fatigue
  • Insomnia
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Side effect rates for Epclusa (velpatasvir / sofosbuvir)

From 1035 clinical trials of Epclusa when taken for hepatitis c
  • Headache
    22%22%
  • Fatigue
    15%15%
  • Nausea
    9%9%
  • Weakness
    5%5%
  • Insomnia
    5%5%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Epclusa.

Epclusa (velpatasvir / sofosbuvir)
Placebo

People taking Epclusa felt side effect more

People taking Epclusa felt side effect less

No difference

Risks and Warnings for Epclusa (velpatasvir / sofosbuvir)

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    • Higher risk if:
    • History of hepatitis B infection

    Before you can start taking Epclusa (velpatasvir / sofosbuvir), your doctor will test you for hepatitis B. If you've ever had hepatitis B, taking Epclusa (velpatasvir / sofosbuvir) for hepatitis C can cause hepatitis B to start up again, which can be very dangerous if it's not caught in time. Tell your doctor if you've ever been treated for hepatitis B.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Epclusa (velpatasvir / sofosbuvir)

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Interactions
  • Epclusa (velpatasvir / sofosbuvir) can interact with other drugs that make it less effective. Make sure your doctor knows about all the medications you're taking, including prescription, over-the-counter, and supplements. They might have to change your other medications while you're taking Epclusa (velpatasvir / sofosbuvir).
Food
  • It can be taken with or without food.
Kidneys and liver
  • Before you can start taking Epclusa (velpatasvir / sofosbuvir), your doctor will test you for hepatitis B. If you've ever had hepatitis B, taking Epclusa (velpatasvir / sofosbuvir) for hepatitis C can cause hepatitis B to start up again, which can be very dangerous if it's not caught in time. Tell your doctor if you've ever been treated for hepatitis B.
  • If you have severe liver disease, you'll have to take Epclusa (velpatasvir / sofosbuvir) with another medication called ribavirin.