Estrogel

(Estradiol)

3.2/ 5 average rating with 78 reviewsforEstrogel
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Relieves hot flashes and vaginal dryness due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Estrogel (Estradiol) is a topical gel that can relieve both vaginal dryness and hot flashes, but needs to be applied across the length your entire arm.

Lowest price near you
  • Price before coupon
    $82.88
  • Lowest price with coupon
    $35.00
    58% savings
Quick facts about Estrogel
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • The pump is easy to use and comes in two different bottle sizes.
  • Good alternative if you don't want to take estrogen pills.
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What to expect from Estrogel, on one page

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People’s experience with Estrogel

78reviews so far. What do you think?

Downsides

  • Available as brand name product only so it may be expensive.
  • Directions for application can be messy and hard to follow.
  • You may unknowingly expose others to the medicine through skin contact.
  • All estrogen replacement therapies are associated with serious side-effects like blood clots, uterine cancer, and breast cancer. You will need to thoroughly discuss the risks and benefits with your doctor before starting treatment.
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What to expect from Estrogel, on one page

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How it works

Estrogel (Estradiol) is a synthetic hormone that acts like estrogen and restores lost functions during menopause.

Quick facts about Estrogel
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Gel
People’s experience with Estrogel

78reviews so far. What do you think?

Prices and coupons

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What to expect when you take Estrogel (Estradiol) for Menopausal symptoms

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Headache
  • Gas
  • Breast pain
  • Skin irritation where applied
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Side effect rates for Estrogel (Estradiol)

From 241 clinical trials of Estrogel when taken for menopausal symptoms (1.25 g/day)
  • Breast pain
    11%11%
    8%8%
  • Headache
    10%10%
    3%3%
  • Gas
    5%5%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Estrogel.

Estrogel (Estradiol)
Placebo

People taking Estrogel felt side effect more

People taking Estrogel felt side effect less

No difference

Risks and Warnings for Estrogel (Estradiol)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterine cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Estrogel (Estradiol) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Estrogel (Estradiol) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Estrogel (Estradiol)

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Price
  • Worth it
    Low hassle
    Reviewed Estrogelon 9/2/2017It's expensive, even with the discount card, it only took $35 off the price, so it's still $84 a month.
    36
    Woman
    Two years or more
    Vaginal dryness and inflammation
Alcohol
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
Sleep
  • Worth it
    Some hassle
    Reviewed Estrogelon 12/5/2016I sleep better since I apply the Estrogel in the morning.
    57
    Woman
    Hot flashes and night sweats