Depo-Estradiol

(estradiol cypionate injection)

3.2/ 5 average rating with 109 reviewsforDepo-Estradiol
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Treats low estrogen and relieves menopause symptoms.

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Our bottom line

Depo-Estradiol (estradiol cypionate injection) is a good once-a-month option for treating menopause symptoms and low estrogen, as long as you're comfortable with needles.

Lowest price near you
  • Retail price
    $118.24
  • Savings
    5%
Quick facts about Depo-Estradiol
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • You only need an injection once a month, which can be less of a hassle than pills, patches, creams, and gels.
  • Your doctor can show you how to inject yourself so you can do it on your own at home.
  • Replenishes estrogen to your whole body and relieves multiple symptoms.
  • Less side effects since lower amounts of estrogen is used compared to the pills.
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What to expect from Depo-Estradiol, on one page

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People’s experience with Depo-Estradiol

109reviews so far. What do you think?

Downsides

  • Requires injection with a needle, which can be difficult for some people.
  • Increases your risk of endometrial and breast cancer.
  • If you have an intact uterus, you have to use Depo-Estradiol (estradiol cypionate injection) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
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What to expect from Depo-Estradiol, on one page

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How it works

The Depo-Estradiol (estradiol cypionate injection) replaces estrogen hormone, which your body loses during menopause. Increasing estrogen relieves hot flashes, night sweats, and vaginal problems.

Quick facts about Depo-Estradiol
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Injection
People’s experience with Depo-Estradiol

109reviews so far. What do you think?

Prices and coupons

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What to expect when you take Depo-Estradiol (estradiol cypionate injection) for Menopause symptoms

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Menstrual changes
  • Nausea
  • Breast pain
  • Libido changes
  • Headache
  • Weight changes
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Side effect rates for Depo-Estradiol (estradiol cypionate injection)

Risks and Warnings for Depo-Estradiol (estradiol cypionate injection)

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    • Higher risk if:
    • Taking estrogen replacement for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Depo-Estradiol (estradiol cypionate injection) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Depo-Estradiol (estradiol cypionate injection) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Depo-Estradiol (estradiol cypionate injection)

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Sex
  • Worth it
    Some hassle
    Reviewed estradiol cypionate injectionon 2/13/2018Had hysterectomy due to uterine fibroids (excessive bleeding) and ovaries removed ( doctor recommended it since I was starting in menopause anyway and my mom had hx of ovarian cyst at about my age). I felt so awful w/o hormones (ie; body aches, hot flashes, heart palps, dryness, insomnia, anxiety, no libido). Hormone injections were an answer to prayer, got my active life back!
    54
    Woman
    Two years or more
    Would rather not say