Vagifem

(Estradiol Vaginal Tablet)

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Relieves vaginal dryness due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Vagifem (Estradiol Vaginal Tablet) is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches.

Lowest price near you
  • Price before coupon
    $82.88
  • Lowest price with coupon
    $35.00
    58% savings
Quick facts about Vagifem
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Vagifem (Estradiol Vaginal Tablet) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
Tried Vagifem? Write a review!

Downsides

  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you might need to use Vagifem (Estradiol Vaginal Tablet) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
How it works

Vagifem (Estradiol Vaginal Tablet) is a vaginal tablet that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.

Quick facts about Vagifem
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Vaginal dryness and inflammation

Dosage forms

  • Vaginal tablet
Tried Vagifem? Write a review!

Prices and coupons

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Side effect rates for Vagifem (Estradiol Vaginal Tablet)

From 308 clinical trials of Vagifem when taken for atrophic vaginitis due to menopause (10 mcg)
  • Vulvovaginal Mycotic infection
    8%8%
    3%3%
  • Vulvovaginal Pruritus
    8%8%
    2%2%
  • Back pain
    7%7%
    2%2%
  • Diarrhea
    5%5%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Vagifem.

Vagifem (Estradiol Vaginal Tablet)
Placebo

People taking Vagifem felt side effect more

People taking Vagifem felt side effect less

No difference

Risks and Warnings for Vagifem (Estradiol Vaginal Tablet)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Vagifem (Estradiol Vaginal Tablet)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Vagifem
XUnsafe
Pain
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Vagifem (Estradiol Vaginal Tablet) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).