Triavil
(perphenazine / amitriptyline)
Treats people with anxiety and/or depression, and people with schizophrenia.
Our bottom line
While Triavil (perphenazine / amitriptyline) can be used to treat people with depression, anxiety, and/or schizophrenia, the limited amount of available combinations makes it harder to customize the dosing.
- Drug class: Neuro/psych
- Rx status: Prescription only
- Generic status: Lower-cost generic available (perphenazine / amitriptyline)
Upsides
- The combination of medicines in Triavil (perphenazine / amitriptyline) is recommended for treating depression with psychotic features.
- Available in generic.
- Convenient to take 1 pill that contains 2 medications.
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What to expect from Triavil, on one page
Download Fact SheetDownsides
- Some doctors believe it's better to take the 2 components of Triavil (perphenazine / amitriptyline) separately, since it's easier to customize.
- You have to take Triavil (perphenazine / amitriptyline) 2 to 4 times a day, which can be hard to remember.
- There are only 5 different combinations available, so customizing a dose can be hard.
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What to expect from Triavil, on one page
Download Fact SheetTriavil (perphenazine / amitriptyline) is a combination of 2 medicines, amitriptyline and perphenazine, which work together to maintain a balance of chemicals in the brain to regulate your mood.
- Drug class: Neuro/psych
- Rx status: Prescription only
- Generic status: Lower-cost generic available (perphenazine / amitriptyline)
Used for
- Depression and/or anxiety
- Schizophrenia
Dosage forms
- Pill
Prices and coupons
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$28.20 - CostcoGet free coupon$41.68
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$45.65
What to expect when you take Triavil (perphenazine / amitriptyline) for Anxiety, depression, and/or schizophrenia
Skip what to expect section. Skip to side effects section.- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Effectiveness
- Starts to kick inFull effects
- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Possible side effects
- Blood pressure changes
- Difficulty controlling movements
- Falls
- Sleepiness
Side effect rates for Triavil (perphenazine / amitriptyline)
Risks and Warnings for Triavil (perphenazine / amitriptyline)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › Under age 24
Taking Triavil (perphenazine / amitriptyline) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Triavil (perphenazine / amitriptyline), call the doctor right away.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Common concerns from people taking Triavil (perphenazine / amitriptyline)
Final section. Do you want to return to drug navigation?The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.
Tip: Always talk with your doctor before you take any medication while pregnant.- Don't drink alcohol or take opioids for pain relief with Triavil (perphenazine / amitriptyline), since the combination can slow your breathing.
- Triavil (perphenazine / amitriptyline) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.