Evamist
(Estradiol Spray)
Relieves hot flashes due to menopause.
Our bottom line
Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Upsides
- Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
- Dries faster than topical estrogen gels.
- Good for people who don't want to take daily pills.
- Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
- Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
- Very few women had skin irritation from the medicine.
- Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
- Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
Downsides
- Increases your risk of endometrial and breast cancer.
- If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
- Increases your risk of developing blood clots and stroke.
- Can't be used in people with liver problems.
- It's possible to expose other people to the estrogen before it's absorbed by your skin.
- Can be expensive since it's only available as a brand name product.
Evamist (Estradiol Spray) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Used for
- Hot flashes and night sweats
Dosage forms
- Spray
Prices and coupons
Skip prices section. Skip to what to expect section.- Medicine ShoppeGet free coupon$134.55
- Rite AidGet free coupon$136.11
Side effect rates for Evamist (Estradiol Spray)
- Headache7%7%4%4%
- Breast tenderness4%4%
- Nasopharyngitis (common cold)4%4%1%1%
- Nipple pain2%2%
- Back pain2%2%1%1%
The placebo bar shows how common a side effect was for people taking a sugar pill instead of Evamist.
People taking Evamist felt side effect more
People taking Evamist felt side effect less
Risks and Warnings for Evamist (Estradiol Spray)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › Using estrogen for more than one year
Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Pharmacist Q&A
Frequently Asked Questions
Who is this drug for?
This medication treats moderate to severe vasomotor symptoms associated with menopause.Common concerns from people taking Evamist (Estradiol Spray)
Final section. Do you want to return to drug navigation?Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.
Tip: Always talk with your doctor before you take any medication while pregnant.- The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
- Can cause nausea, dizziness, bloating, and breast tenderness.