Duragesic

(fentanyl)

4.2/ 5 average rating with 84 reviewsforfentanyl
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Treats severe pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Duragesic (fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.

Lowest price near you
  • Lowest price with coupon
    $284.81
Quick facts about fentanyl
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (fentanyl)

Upsides

  • Duragesic (fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
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What to expect from fentanyl, on one page

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People’s experience with fentanyl

84reviews so far. What do you think?

Downsides

  • Duragesic (fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • The patch doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If taking long-term, use a stool softener.
  • Shouldn't be used by people with breathing problems (like asthma and COPD), a slow heart rate, or are elderly.
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What to expect from fentanyl, on one page

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How it works

Duragesic (fentanyl) is an opioid (narcotic) medication that works in the brain to lower pain perception.

Quick facts about fentanyl
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (fentanyl)

Dosage forms

  • Patch
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
People’s experience with fentanyl

84reviews so far. What do you think?

Prices and coupons

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What to expect when you take Duragesic (fentanyl) for Severe pain

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  • First few hoursHours
    First few daysDays
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  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Nausea
  • Drowsiness
  • Constipation
  • Vomiting
  • Dizziness
  • Headache
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Side effect rates for Duragesic (fentanyl)

From 254 clinical trials of fentanyl when taken for chronic pain
  • Vomiting
    34%34%
  • Nausea
    24%24%
  • Dizziness
    17%17%
  • Drowsiness
    17%17%
  • Headache
    16%16%
  • Constipation
    13%13%
  • Diarrhea
    13%13%
  • Itchy skin
    13%13%
  • Vomiting
    12%12%
  • Headache
    12%12%
  • Diarrhea
    10%10%
  • Weakness
    9%9%
  • Abdominal pain
    9%9%
  • Headache
    6%6%
  • Difficulty sleeping
    6%6%
  • Rash
    6%6%
  • Swelling in the limbs
    5%5%
  • Drowsiness
    5%5%
  • Constipation
    4%4%
  • Confusion
    4%4%
  • Difficulty breathing
    4%4%
  • Upper abdominal pain
    4%4%
  • Loss of appetite
    4%4%
  • Anxiety
    4%4%
  • Abdominal pain
    3%3%
  • Tremor
    3%3%
  • Anxiety
    3%3%
  • Hypersensitivity
    3%3%
  • Urinary retention
    3%3%
  • Sweating
    3%3%
  • Rash
    3%3%
  • Accidental injury
    2%2%
  • Abnormal gait
    2%2%
  • Dry mouth
    2%2%
  • Nervousness
    2%2%
  • Dilation of blood vessels
    2%2%
  • Itchy skin
    2%2%
  • Rash
    2%2%
  • Sweating
    2%2%
  • Abnormal vision
    2%2%
  • Burning/pricking sensation
    2%2%
  • Confusional state
    2%2%
  • Dry mouth
    2%2%
  • Fatigue
    2%2%
  • Muscle spasms
    2%2%
  • Dizziness
    2%2%
  • Tremor
    2%2%
  • Depression
    2%2%
  • Hallucination
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of fentanyl.

Duragesic (fentanyl)
Placebo

People taking fentanyl felt side effect more

People taking fentanyl felt side effect less

No difference

Risks and Warnings for Duragesic (fentanyl)

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    • Higher risk if:
    • Taking other medicines that interact with Duragesic (fentanyl)
    • Age 65 or greater
    • Taking benzodiazepines, other opioids, and/or alcohol
    • Asthma or COPD

    Taking too much Duragesic (fentanyl) can cause irregular or slow breathing that can put you in a coma and cause death. Your risk is greater if you drink alcohol, take other opioid medications, or take benzodiazepines. If you have asthma or COPD, taking Duragesic (fentanyl) is generally not recommended. If you start to feel like you can't breathe or your lips and fingers are turning blue, go to a hospital immediately. Many drugs interact with Duragesic (fentanyl) and affect its levels in your blood, including some antibiotics, HIV medications, and anti-seizure medications. Always check with your doctor before starting or stopping any new medications or supplements.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Duragesic (fentanyl)

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Alcohol
  • Never drink alcohol when using Duragesic (fentanyl).
Pain
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
  • Duragesic (fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • Worth it
    Low hassle
    Reviewed fentanylon 4/19/2017Make sure that you have your pain under control before using the patch: try to schedule on evenings before re-patching. then shower,dry well, wipe off( w/Alcohol) large area to apply the patch , then pressure HARD for 30 seconds .Place a 3"x4"Tegaderm skin patch over it, to make sure it stays stuck through the next 72 hours. Go to Amazon to see the offers on a roll of 4"x 396"(11yards) .My rolls cost about 33$. single box of 10 Tegaderm patches 3.5" X 4" was 10$
    63
    Man
    Continued pain after other treatments
  • Not sure
    Some hassle
    Reviewed fentanylon 12/27/2016I used 25s for pain control after having back surgery. I had a terrible time keeping it on my skin. 3 days was too long for it to stay sticky enough plus the package material says not to use any kind of tape to keep it on. It said to use tegederm to keep it on and what I was told those are expensive. The whole time I had to use the dilaudid for break through pain. I felt like the patches just did not work for the trouble it caused while in pain.
    40
    Woman
    Cancer pain
  • Worth it
    Low hassle
    Reviewed fentanylMajor Full body Nerve pain, In beginning 50mcg 72h w Oxycodone 10MG as needed for BT. After 5yrs BT GONE!! Only 50mcg 48h only kept BT's just in case needed 10yrs now 50mcg 48h CANCELED by PC BY Directive.
    52
    Man
    Two years or more
    Long-term nerve pain (severe)
Sleep
  • Can make you sleepy and dizzy. Avoid driving or other activities that require alertness until you know how Duragesic (fentanyl) affects you.
  • Often causes drowsiness and constipation. If taking long-term, use a stool softener.
  • Not worth it
    Big hassle
    Reviewed fentanylon 2/20/2017It made me sleep the whole time I was on it . Nasty med. for me.
    64
    Woman
    Long-term pain (severe)