(Butalbital / Acetaminophen / Caffeine)

4.3/ 5 average rating with 17 reviewsforFioricet
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Treats tension headaches.

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Our bottom line

Fioricet (Butalbital / Acetaminophen / Caffeine) works well for tension headaches, but isn’t recommended due to the ability to overuse it and have withdrawal symptoms.

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Quick facts about Fioricet
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (butalbital / acetaminophen / caffeine)


  • Fioricet (Butalbital / Acetaminophen / Caffeine) works better and faster in treating tension headaches than the combination of acetaminophen and codeine.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) doesn’t cost much since it's available as a generic medication.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) has very few side effects.
  • It has been widely used for a long time.
People’s experience with Fioricet

17reviews so far. What do you think?


  • Fioricet (Butalbital / Acetaminophen / Caffeine) isn't the first choice medication for treating tension headaches.
  • It's not a good medication for long-term use.
  • Overuse of Fioricet (Butalbital / Acetaminophen / Caffeine) can lead to chronic tension headaches.
  • Fioricet (Butalbital / Acetaminophen / Caffeine) can cause dangerous withdrawal symptoms, intoxication, and dependence.
  • Taking Fioricet (Butalbital / Acetaminophen / Caffeine) can decrease your ability to drive a car, or operate machinery.
How it works

Fioricet (Butalbital / Acetaminophen / Caffeine) is a combination of three medications. Butalbital is a barbiturate that relaxes you. Acetaminophen relieves pain, and caffeine narrows the blood vessels that otherwise cause headaches.

Quick facts about Fioricet
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (butalbital / acetaminophen / caffeine)

Dosage forms

  • Pill
  • Oral solution
People’s experience with Fioricet

17reviews so far. What do you think?

Prices and coupons

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Side effect rates for Fioricet (Butalbital / Acetaminophen / Caffeine)

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These are side effects of Fioricet (Butalbital / Acetaminophen / Caffeine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Fioricet (Butalbital / Acetaminophen / Caffeine)

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    • Higher risk if:
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other acetaminophen-containing medicines
    • History of liver disease

    Fioricet (Butalbital / Acetaminophen / Caffeine) contains acetaminophen, also known as Tylenol or APAP. Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Using more than 3000 mg of the acetaminophen can cause serious harm to your liver, so be sure not to take more than the recommended dose of Fioricet (Butalbital / Acetaminophen / Caffeine) or other medications that contain acetaminophen.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Fioricet (Butalbital / Acetaminophen / Caffeine)

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Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Fioricet
CWeigh risks vs. benefits
  • Worth it
    Low hassle
    Reviewed Fioriceton 6/27/2016Just be careful and not drink alcohol or take other pain relievers at the same time.
    Tension headache
Kidneys and liver
  • Worth it
    Low hassle
    Reviewed Fioriceton 3/30/2017Wish I knew about liver disease. I have one kidney and my PCP hasn't done any regular blood tests , I hope my organs are okay ! I've taken 4-5 pills for the past 5 years without any issues. A real great painkiller for neck/headache pain.
    Two years or more
    Muscle contraction
  • Not worth it
    Some hassle
    Reviewed Fioriceton 9/2/2017Use natural remedies along with diet to control pain onset & spikes.
    A few months
    Tension headache