Gablofen

(baclofen)

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Works well to control muscle spasticity.

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Our bottom line

Gablofen (baclofen) is effective for long term spastic conditions, such as multiple sclerosis, spinal cord injury, and others. It is administered intrathecally by a pump connecting to your spine.

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    $37.61
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Quick facts about Gablofen
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (baclofen)

Upsides

  • Gablofen (baclofen) is the agent of choice for treatment of muscle spasticity.
  • Gablofen (baclofen) has fewer side effects than the oral form, since higher levels can be delivered to the spine at lower doses.
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What to expect from Gablofen, on one page

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Downsides

  • Gablofen (baclofen) can cause sleepiness and drowsiness.
  • Stopping Gablofen (baclofen) right away can be life-threatening, so a doctor would need to help you stop it.
  • Gablofen (baclofen) has to be started in the doctor's office. You or your caregiver need to be trained on how to use the pump.
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How it works

Gablofen (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It lowers nerve reflex activity in the spinal cord.

Quick facts about Gablofen
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (baclofen)

Dosage forms

  • Injection
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Prices and coupons

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What to expect when you take Gablofen (baclofen) for muscle spasticity

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  • First few hoursHours
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  • Effectiveness
  • Full effects
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  • Possible side effects
  • Drowsiness
  • Inability to urinate
  • Dizziness
  • Nausea
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Side effect rates for Gablofen (baclofen)

From 150 clinical trials of Gablofen when taken for muscle spasticity of cerebral origin (gablofen intrathecal variable maintenance doses)
  • Loss of muscle tone
    35%35%
  • Drowsiness
    19%19%
  • Headache
    11%11%
  • Convulsion
    10%10%
  • Urinary Retention
    8%8%
  • Dizziness
    8%8%
  • Nausea
    7%7%
  • Increased muscle tone
    6%6%
  • Vomiting
    4%4%
  • Slowed breathing
    4%4%
  • Pain
    4%4%
  • Itchiness
    4%4%
  • Increased salivation
    3%3%
  • Swelling of limbs
    3%3%
  • Back pain
    2%2%
  • Constipaiton
    2%2%
  • Diarrhea
    2%2%
  • Weak muscles
    2%2%
  • Pneumonia
    2%2%
  • Urination control problems
    2%2%
  • Inability to urinate
    2%2%
0%
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80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Gablofen.

Gablofen (baclofen)
Placebo

People taking Gablofen felt side effect more

People taking Gablofen felt side effect less

No difference

Risks and Warnings for Gablofen (baclofen)

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    • Higher risk if:
    • Stopping Gablofen (baclofen) too quickly

    If you've been taking Gablofen (baclofen) for a while, stopping it suddenly can be dangerous. People have had fevers, rebound spasticity, muscle rigidity, and altered mental status. This can be life-threatening. Talk to your doctor about stopping it slowly so this doesn't happen to you.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Gablofen (baclofen)

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Sleep
  • Gablofen (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Gablofen (baclofen) can cause sleepiness and drowsiness.