Glyburide / Metformin

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Lowers blood sugar.

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Our bottom line

Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.

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    $14.28
Quick facts about Glucovance
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Generic only

Upsides

  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
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What to expect from Glucovance, on one page

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Downsides

  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
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What to expect from Glucovance, on one page

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How it works

Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.

Quick facts about Glucovance
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Generic only

Dosage forms

  • Pill
Tried Glucovance? Write a review!

Prices and coupons

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What to expect when you take Glyburide / Metformin for Type 2 diabetes

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain)
  • Diarrhea
  • Upper respiratory infection
  • Low blood sugar
  • Headache
  • Dizziness
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Side effect rates for Glyburide / Metformin

From 803 clinical trials of Glucovance when taken for type 2 diabetes
  • Upper respiratory infection
    17%17%
    14%14%
  • Diarrhea
    17%17%
    6%6%
  • Headache
    9%9%
    11%11%
  • Nausea/vomiting
    8%8%
    6%6%
  • Stomach pain
    7%7%
    4%4%
  • Dizziness
    6%6%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Glucovance.

Glyburide / Metformin
Placebo

People taking Glucovance felt side effect more

People taking Glucovance felt side effect less

No difference

Risks and Warnings for Glyburide / Metformin

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    • Higher risk if:
    • History of kidney problems
    • History of liver problems
    • Those with congestive heart failure
    • Using contrast dye for procedures
    • Undergoing surgery
    • Drinking large amounts or frequent use of alcohol

    Glyburide / Metformin can cause the buildup of a chemical called lactate in your blood which can result in a rare, but life-threatening condition known as lactic acidosis. Symptoms of lactic acidosis include shallow and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Speak to your doctor first before using Glyburide / Metformin if you have kidney and/or liver problems.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Glyburide / Metformin questions for

Frequently Asked Questions

This medication treats Type 2 Diabetes, either alone or in combination with other treatments.

Who is this drug for?

This medication treats Type 2 Diabetes, either alone or in combination with other treatments.

Common concerns from people taking Glyburide / Metformin

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Alcohol
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
Kidneys and liver
  • Not a good treatment option for those with kidney and/or liver problems.
Weight
  • Can cause some weight gain.