Glucovance

(glyburide / metformin)

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Lowers blood sugar.

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Glucovance (glyburide / metformin) is single-pill combination of two first-choice medicines for diabetes, but it can cause hypoglycemia (low blood sugar).

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    $83.80
Quick facts about glyburide / metformin
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (glyburide / metformin)

Upsides

  • Combination works better than the sum of the individual components.
  • May lower the level of certain blood fats (triglycerides and cholesterol).
  • One of the few single-pill combination medicines that is available as a generic version
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What to expect from glyburide / metformin, on one page

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Downsides

  • More likely to cause hypoglycemia or low blood sugar than with other anti-diabetic medicines.
  • Can cause upset stomach or diarrhea.
  • Not a good option if you have bad kidneys or liver.
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What to expect from glyburide / metformin, on one page

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How it works

Glucovance (glyburide / metformin) contains 2 anti-diabetic medicines. Glyburide stimulates your body to release more insulin, while metformin makes your body more sensitive to insulin.

Quick facts about glyburide / metformin
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (glyburide / metformin)

Dosage forms

  • Pill
Tried glyburide / metformin? Write a review!

Prices and coupons

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What to expect when you take Glucovance (glyburide / metformin) for Type 2 diabetes

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Stomach problems
  • Diarrhea
  • Upper respiratory infection
  • Low blood sugar
  • Headache
  • Dizziness
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Side effect rates for Glucovance (glyburide / metformin)

From 803 clinical trials of glyburide / metformin when taken for type 2 diabetes
  • Upper respiratory infection
    17%17%
    14%14%
  • Diarrhea
    17%17%
    6%6%
  • Headache
    9%9%
    11%11%
  • Nausea and vomiting
    8%8%
    6%6%
  • Abdominal pain
    7%7%
    4%4%
  • Dizziness
    6%6%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of glyburide / metformin.

Glucovance (glyburide / metformin)
Placebo

People taking glyburide / metformin felt side effect more

People taking glyburide / metformin felt side effect less

No difference

Risks and Warnings for Glucovance (glyburide / metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use

    Glucovance (glyburide / metformin) can cause lactic acidosis, a rare but life-threatening condition. You may have trouble breathing and be nauseas or vomit. This is a medical emergency and you should get help right away. This is more likely to happen if you have poor kidneys or was given contrast dye before an imaging procedure.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Glucovance (glyburide / metformin)

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Alcohol
  • Try limiting the amount of alcohol you drink while taking this medicine.
Food
  • Take with meals to prevent upset stomach.
Kidneys and liver
  • Not a good option if you have bad kidneys or liver.