Glyxambi

(empaglifozin / linagliptin)

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Lowers blood sugar.

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Our bottom line

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

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  • Lowest price with coupon
    $528.45
Quick facts about Glyxambi
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
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What to expect from Glyxambi, on one page

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Downsides

  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
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What to expect from Glyxambi, on one page

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How it works

Glyxambi (empaglifozin / linagliptin) contains 2 anti-diabetes medicines. Empagliflozin lowers blood sugar by increasing secretion of blood sugar into your urine, while linagliptin helps your body produce more insulin and less glucagon.

Quick facts about Glyxambi
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Glyxambi? Write a review!

Prices and coupons

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What to expect when you take Glyxambi (empaglifozin / linagliptin) for Type 2 diabetes

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  • Effectiveness
  • Starts to kick in
    Full effects
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  • Possible side effects
  • Urinary tract infection
  • Common cold
  • Upper respiratory tract infection
  • Low blood sugar
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Side effect rates for Glyxambi (empaglifozin / linagliptin)

From 272 clinical trials of Glyxambi when taken for type 2 diabetes (empagliflozin 10 mg + linagliptin 5 mg)
  • Urinary tract infection
    13%13%
  • Upper respiratory tract infection
    7%7%
  • Common cold
    6%6%
  • Low blood sugar
    2%2%
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Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Glyxambi.

Glyxambi (empaglifozin / linagliptin)
Placebo

People taking Glyxambi felt side effect more

People taking Glyxambi felt side effect less

No difference

Risks and Warnings for Glyxambi (empaglifozin / linagliptin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Alcohol use
    • Age 65 or older
    • Surgery
    • Contrast Dye
    • Congestive heart failure
    • Calorie restriction

    Glyxambi (empaglifozin / linagliptin) may cause a dangerous build up of acid in your body, known as ketoacidosis. Stop taking Glyxambi (empaglifozin / linagliptin) and contact your doctor right away if you experience nausea, vomiting, abdominal pain, tiredness, or trouble breathing.

Common concerns from people taking Glyxambi (empaglifozin / linagliptin)

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Food
  • Take in the morning by mouth with or without food.
Kidneys and liver
  • Rarely, Glyxambi (empaglifozin / linagliptin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Glyxambi (empaglifozin / linagliptin).
  • May not be good for people who have kidney problems.
Weight
  • Can cause weight loss.