Hyzaar

(Losartan / Hydrochlorothiazide)

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Lowers blood pressure. Removes extra water from your body.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.

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Quick facts about Hyzaar
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (losartan / hydrochlorothiazide)

Upsides

  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.
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Downsides

  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.
How it works

Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.

Quick facts about Hyzaar
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (losartan / hydrochlorothiazide)

Used for

Dosage forms

  • Pill
Tried Hyzaar? Write a review!

Prices and coupons

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Side effect rates for Hyzaar (Losartan / Hydrochlorothiazide)

From 1031 clinical trials of Hyzaar when taken for high blood pressure
  • Dizziness
    6%6%
    3%3%
  • Upper respiratory infection
    6%6%
    5%5%
  • Cough   
    3%3%
    2%2%
  • Back pain
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Hyzaar.

Hyzaar (Losartan / Hydrochlorothiazide)
Placebo

People taking Hyzaar felt side effect more

People taking Hyzaar felt side effect less

No difference

Risks and Warnings for Hyzaar (Losartan / Hydrochlorothiazide)

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    • Higher risk if:
    • › Women of childbearing age

    Losartan in Hyzaar (Losartan / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Hyzaar (Losartan / Hydrochlorothiazide) questions for

Frequently Asked Questions

This medication treats hypertension (high blood pressure).

Who is this drug for?

This medication treats hypertension (high blood pressure).

Common concerns from people taking Hyzaar (Losartan / Hydrochlorothiazide)

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Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Hyzaar
DWeigh risks vs. benefits
Kidneys and liver
  • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
  • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Needs dose adjustment if you have liver problems.