Inspra

(eplerenone)

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Helps lower blood pressure and protect the heart in people with heart failure.

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Our bottom line

Inspra (eplerenone) lowers blood pressure and can help remove fluid when it's used with other drugs. It reduces the risk of death in people with heart failure and is usually used when people can't take spironolactone.

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Quick facts about Inspra
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (eplerenone)

Upsides

  • Lowers your blood pressure.
  • It can help remove fluid from your body when it's used with other drugs.
  • Reduces the risk of death in people with heart failure.
  • It can have fewer side effects than spironolactone.
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What to expect from Inspra, on one page

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Downsides

  • Inspra (eplerenone) isn't a first choice medicine for lowering blood pressure or getting rid of fluid in the body. It's usually used in combination with other medicines.
  • It can make you feel dizzy for the first few days. Be careful driving until you know how it affects you.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.
  • It can be very expensive compared to spironolactone.
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What to expect from Inspra, on one page

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How it works

Inspra (eplerenone) is an aldosterone antagonist. It blocks aldosterone (a hormone) and helps your kidneys get rid of excess fluid in your body, which helps lower blood pressure.

Quick facts about Inspra
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (eplerenone)

Used for

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Inspra (eplerenone) for High blood pressure

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Dizziness
  • Diarrhea
  • Breast tenderness
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Side effect rates for Inspra (eplerenone)

From 6608 clinical trials of Inspra when taken for heart failure
  • High potassium
    3%3%
    2%2%
  • Abnormal renal function
    3%3%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Inspra.

Inspra (eplerenone)
Placebo

People taking Inspra felt side effect more

People taking Inspra felt side effect less

No difference

Risks and Warnings for Inspra (eplerenone)

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    • Higher risk if:
    • › Taking with alcohol
    • › Taking other medicines that lower your blood pressure

    Inspra (eplerenone) lowers your blood pressure and can make you feel lightheaded or dizzy. This should go away after a few days, but talk to your doctor if it doesn't. They may change your dose or put you on a different medication.

Pharmacist Q&A

Inspra (eplerenone) questions for

Frequently Asked Questions

This medication reduces fatalities in individuals with congestive heart failure after a heart attack (myocardial infarction).

Who is this drug for?

This medication reduces fatalities in individuals with congestive heart failure after a heart attack (myocardial infarction).

Common concerns from people taking Inspra (eplerenone)

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Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Inspra
BProbably safe
Kidneys and liver
  • Inspra (eplerenone) shouldn't be used by people with bad kidneys since it can hurt your kidneys or cause worse side effects, such as high potassium levels. Your doctor will do frequent blood tests to monitor your kidney function and electrolytes while you're on this drug.
  • Shouldn't be used by people with kidney or liver damage.
  • You'll need to have blood tests done regularly since Inspra (eplerenone) can affect your potassium levels and kidney function.