Invokamet

(canagliflozin / metformin)

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Lowers blood sugar.

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Our bottom line

Invokamet (canagliflozin / metformin) is a combination of 2 medicines that can lower your blood sugars, but it still has to be taken twice daily.

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    $469.88
Quick facts about Invokamet
  • Drug class: endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
  • Does not cause weight gain unlike other anti-diabetic medicines.
  • Not as likely to cause hypoglycemia (low blood sugar)
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What to expect from Invokamet, on one page

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Downsides

  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
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What to expect from Invokamet, on one page

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How it works

Invokamet (canagliflozin / metformin) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.

Quick facts about Invokamet
  • Drug class: endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Invokamet? Write a review!

Prices and coupons

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What to expect when you take Invokamet (canagliflozin / metformin) for Type 2 diabetes

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  • Effectiveness
  • Full effects
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  • Possible side effects
  • Urinary tract infections
  • Yeast infection in women
  • Thirst
  • Low blood pressure
  • Increased urination
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Side effect rates for Invokamet (canagliflozin / metformin)

From 737 clinical trials of Invokamet when taken for type 2 diabetes (100 mg)
  • Yeast infection in women
    11%11%
    3%3%
  • Urinary tract infections
    6%6%
    4%4%
  • Increased urination
    5%5%
    1%1%
  • Yeast infection in men
    4%4%
    1%1%
  • Thirst
    3%3%
  • Vaginal itching
    2%2%
  • Constipation
    2%2%
    1%1%
  • Nausea
    2%2%
    2%2%
  • Abdominal pain
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Invokamet.

Invokamet (canagliflozin / metformin)
Placebo

People taking Invokamet felt side effect more

People taking Invokamet felt side effect less

No difference

Risks and Warnings for Invokamet (canagliflozin / metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use

    Invokamet (canagliflozin / metformin) can cause lactic acidosis, a rare but life-threatening condition of acid build up in your blood. Symptoms include trouble breathing, nausea, vomiting, and stomach or muscle pain and you should get emergency medical help or call your doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Invokamet (canagliflozin / metformin)

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Food
  • Take with meals to avoid an upset stomach.
Kidneys and liver
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
Pain
  • Invokamet (canagliflozin / metformin) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet (canagliflozin / metformin).
Weight
  • Does not cause weight gain unlike other anti-diabetic medicines.