Invokamet-XR

(canagliflozin / metformin extended release)

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Lowers blood sugar.

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Our bottom line

Invokamet-XR (canagliflozin / metformin extended release) is a combination of 2 medicines that lower your blood sugars, but it can be expensive.

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    $469.88
Quick facts about Invokamet XR
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Can be taken once a day.
  • Combines 2 effective anti-diabetes medicines into one pill so you don't have to take them separately.
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What to expect from Invokamet XR, on one page

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Downsides

  • Not a good option if you have worsening kidney function such as those age 65 years and up.
  • May cause increased urination.
  • More likely to cause broken bones and yeast and urinary tract infections.
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What to expect from Invokamet XR, on one page

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How it works

Invokamet-XR (canagliflozin / metformin extended release) is a combination of anti-diabetes medicines. Metformin lowers blood sugar by enhancing your body's response to insulin, while canagliflozin increases your body's secretion of sugar through the urine.

Quick facts about Invokamet XR
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Invokamet XR? Write a review!

Prices and coupons

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What to expect when you take Invokamet-XR (canagliflozin / metformin extended release) for Type 2 diabetes

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  • Effectiveness
  • Full effects
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  • Possible side effects
  • Urinary tract infections
  • Yeast infection in women
  • Thirst
  • Low blood pressure
  • Increased urination
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Side effect rates for Invokamet-XR (canagliflozin / metformin extended release)

From 737 clinical trials of Invokamet XR when taken for type 2 diabetes (100 mg)
  • Yeast infection in women
    11%11%
    3%3%
  • Urinary tract infections
    6%6%
    4%4%
  • Increased urination
    5%5%
    1%1%
  • Yeast infection in men
    4%4%
    1%1%
  • Thirst
    3%3%
  • Vaginal itching
    2%2%
  • Constipation
    2%2%
    1%1%
  • Nausea
    2%2%
    2%2%
  • Abdominal pain
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Invokamet XR.

Invokamet-XR (canagliflozin / metformin extended release)
Placebo

People taking Invokamet XR felt side effect more

People taking Invokamet XR felt side effect less

No difference

Risks and Warnings for Invokamet-XR (canagliflozin / metformin extended release)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use

    Invokamet-XR (canagliflozin / metformin extended release) can cause lactic acidosis, a rare but life-threatening condition of acid build up in your blood. Symptoms include trouble breathing, nausea, vomiting, and stomach or muscle pain and you should get emergency medical help or call your doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Invokamet-XR (canagliflozin / metformin extended release)

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Food
  • Take with meals to avoid an upset stomach.
Kidneys and liver
  • Not a good option if you have worsening kidney function such as those age 65 years and up.
Pain
  • Invokamet-XR (canagliflozin / metformin extended release) can, in very rare cases, hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or are taking medicines for blood pressure or pain like NSAIDs. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokamet-XR (canagliflozin / metformin extended release).