Janumet

(sitagliptin / metformin)

3.4/ 5 average rating with 79 reviewsforJanumet
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Lowers your blood sugar.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

Lowest price near you
  • Retail price
    $483.67
  • Savings
    10%
Quick facts about Janumet
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
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What to expect from Janumet, on one page

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People’s experience with Janumet

79reviews so far. What do you think?

Downsides

  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
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What to expect from Janumet, on one page

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How it works

Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.

Quick facts about Janumet
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
  • Extended release
People’s experience with Janumet

79reviews so far. What do you think?

Prices and coupons

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What to expect when you take Janumet (sitagliptin / metformin) for Type 2 diabetes

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Diarrhea
  • Upper respiratory tract infection
  • Headache
  • Nausea
  • Vomiting
  • Abdominal pain
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Side effect rates for Janumet (sitagliptin / metformin)

From 548 clinical trials of Janumet when taken for type 2 diabetes
  • Low blood sugar
    16%16%
    1%1%
  • Diarrhea
    8%8%
    4%4%
  • Upper respiratory tract infection
    6%6%
    5%5%
  • Headache
    6%6%
    3%3%
  • Diarrhea
    2%2%
    3%3%
  • Abdominal pain
    2%2%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Janumet.

Janumet (sitagliptin / metformin)
Placebo

People taking Janumet felt side effect more

People taking Janumet felt side effect less

No difference

Risks and Warnings for Janumet (sitagliptin / metformin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use

    Janumet (sitagliptin / metformin) can cause excess acid to build up in your blood. This is a rare life-threatening condition. You're more likely to get this if you already have kidney problems, are having surgery or any imaging that needs contrast dye. Your doctor will check your kidneys and liver functions before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Janumet (sitagliptin / metformin) questions for

Frequently Asked Questions

This medication treats type 2 diabetes in adults..

Who is this drug for?

This medication treats type 2 diabetes in adults..

Common concerns from people taking Janumet (sitagliptin / metformin)

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Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Janumet
BProbably safe
Food
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • Worth it
    Some hassle
    Reviewed Janumeton 3/3/2017Take with food to avoid an upset stomach. Drink lots of water.
    44
    Woman
    Two years or more
    Type 2 diabetes
Kidneys and liver
  • Not appropriate for those with poor kidney function.
Weight
  • Worth it
    Low hassle
    Reviewed Janumeton 9/27/2016it's just very expensive! No side effects that I can tell. Lost quite a bit of weight too (obviously watching my diet and limiting carbs and sugars).
    70
    Woman
    Type 2 diabetes