Kombiglyze

(metformin / saxagliptin)

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Lowers blood sugar.

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Our bottom line

Kombiglyze (metformin / saxagliptin) works well to lower blood sugar, but may not be a good option if you have heart or kidney problems.

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    $394.52
Quick facts about Kombiglyze
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Combines two anti-diabetic medicines for convenient once daily dosing.
  • Does not cause weight gain unlike insulin therapy.
  • Less likely to cause episodes of low blood sugar compared to other anti-diabetic medicines.
  • Does not cause heart failure unlike some other anti-diabetic medicines that work like it.
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What to expect from Kombiglyze, on one page

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Downsides

  • Expensive if not covered by your insurance.
  • There is less flexibility with dose adjustments with this single-pill, fixed-dose combination.
  • Not a good option if you have arthritis or other existing joint problems.
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How it works

Kombiglyze (metformin / saxagliptin) is a combination of two medicines, metformin and saxagliptin, for diabetes. Saxagliptin enhances your body's release of insulin around meal times, while metformin increases your body's response to insulin.

Quick facts about Kombiglyze
  • Drug class: Endocrine
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Pill
Tried Kombiglyze? Write a review!

Prices and coupons

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What to expect when you take Kombiglyze (metformin / saxagliptin) for Type 2 diabetes

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  • Effectiveness
  • Starts to kick in
    Full effects
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  • Possible side effects
  • Urinary tract infection
  • Headache
  • Common cold
  • Diarrhea
  • Low blood sugar
  • Severe joint pain
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Side effect rates for Kombiglyze (metformin / saxagliptin)

Risks and Warnings for Kombiglyze (metformin / saxagliptin)

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    • Higher risk if:
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Using contrast dye for procedures
    • Surgery
    • Alcohol use

    Kombiglyze (metformin / saxagliptin) can cause build up of lactic acid in the blood. Your doctor will check your kidneys and liver before you start. You're more likely to develop this condition if you have poor kidney function. Get medical help right away if you experience deep and rapid breathing, nausea, vomiting, or stomach pain. Kombiglyze (metformin / saxagliptin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Kombiglyze (metformin / saxagliptin)

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Weight
  • Does not cause weight gain unlike insulin therapy.