Limbitrol

(chlordiazepoxide / amitriptyline)

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Treats anxiety and depression.

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Our bottom line

While Limbitrol (chlordiazepoxide / amitriptyline) as a combination can be used to treat both anxiety and depression, other medicines are considered first choice because chlordiazepoxide can be potentially addicting.

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    $36.59
Quick facts about chlordiazepoxide / amitriptyline
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (chlordiazepoxide / amitriptyline)

Upsides

  • Limbitrol (chlordiazepoxide / amitriptyline) is available as a generic.
  • Limbitrol (chlordiazepoxide / amitriptyline) works faster than amitriptyline alone.
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Downsides

  • Limbitrol (chlordiazepoxide / amitriptyline) is only available in certain strengths, so it can be difficult to customize a dose that treats both anxiety and depression.
  • Limbitrol (chlordiazepoxide / amitriptyline) contains chlordiazepoxide, which can be potentially addicting.
  • You might not notice any changes in your mood until you've been taking Limbitrol (chlordiazepoxide / amitriptyline) for several weeks.
  • Amitriptyline alone is considered a better treatment for anxiety and depression than Limbitrol (chlordiazepoxide / amitriptyline).
  • Other medicines are considered first choice for treating anxiety and depression over Limbitrol (chlordiazepoxide / amitriptyline).
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What to expect from chlordiazepoxide / amitriptyline, on one page

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How it works

Limbitrol (chlordiazepoxide / amitriptyline) is a combination of 2 medicines. Chlordiazepoxide is a benzodiazepine, and it calms activity in a part of the brain responsible for emotional responses. Amitriptyline is a tricyclic antidepressant, and it raises the amount of norepinephrine and serotonin in the brain, which can improve mood.

Quick facts about chlordiazepoxide / amitriptyline
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (chlordiazepoxide / amitriptyline)

Used for

  • Anxiety and depression

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Limbitrol (chlordiazepoxide / amitriptyline) for Anxiety & depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Vision changes
  • Drowsiness
  • Dry mouth
  • Constipation
  • Dizziness
  • Bloating
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Side effect rates for Limbitrol (chlordiazepoxide / amitriptyline)

Risks and Warnings for Limbitrol (chlordiazepoxide / amitriptyline)

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    • Higher risk if:
    • People under age 24

    Taking Limbitrol (chlordiazepoxide / amitriptyline) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Limbitrol (chlordiazepoxide / amitriptyline), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Limbitrol (chlordiazepoxide / amitriptyline)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for chlordiazepoxide / amitriptyline
CWeigh risks vs. benefits
Alcohol
  • Don't drink alcohol or take narcotics, tranquilizers, or antihistamines if you're taking Limbitrol (chlordiazepoxide / amitriptyline). This can slow down your breathing. Talk to your doctor if this is a problem.
  • Don't drink alcohol or take any narcotics while taking Limbitrol (chlordiazepoxide / amitriptyline) since it can slow your breathing.
Sleep
  • Limbitrol (chlordiazepoxide / amitriptyline) can make you sleepy and unable to focus, so don't drive or do anything requiring concentration for a few hours after taking it until you know how it affects you. This can be worse if you drink alcohol or take narcotics.