Activella

(estradiol / norethindrone)

Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Relieves menopause symptoms and lowers your risk of osteoporosis.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Activella (estradiol / norethindrone) helps relieve menopausal symptoms and prevent bone loss. There can be many side effects, so it's important to talk to your doctor about the benefits and potential hassles of this drug before using it.

Lowest price near you
  • Price before coupon
    $106.99
  • Lowest price with coupon
    $42.85
    60% savings
Quick facts about estradiol / norethindrone
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (estradiol / norethindrone)

Upsides

  • Replaces estrogen in your entire body and relieves multiple symptoms of menopause.
  • Lowers your risk of fractures by keeping your bones healthy.
  • Improves mood, energy, and mental alertness for some people.
  • Generic available, so cost is usually lower.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from estradiol / norethindrone, on one page

Download Fact Sheet
Tried estradiol / norethindrone? Write a review!

Downsides

  • More potential side effects since Activella (estradiol / norethindrone) exposes your whole body to two hormones.
  • Raises your risk of developing a stroke and blood clots.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Should only use if you still have a uterus.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from estradiol / norethindrone, on one page

Download Fact Sheet
How it works

Activella (estradiol / norethindrone) is a combination pill that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes, night sweats, and vaginal dryness. Norethindrone (a progestin) protects the uterus from damage.

Quick facts about estradiol / norethindrone
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (estradiol / norethindrone)

Used for

  • Hot flashes
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis

Dosage forms

  • Pill
Tried estradiol / norethindrone? Write a review!

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 1 (28-tablets-of-0.5mg-0.1mg) package of estradiol / norethindrone near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Activella (estradiol / norethindrone) for Hot flashes

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Breast pain
  • Headache
  • Post-menopausal bleeding
  • Nausea
  • Upper airway infection
  • Sinus infection
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Activella (estradiol / norethindrone)

From 63 clinical trials of estradiol / norethindrone when taken for hot flashes
  • Breast pain
    21%21%
  • Headache
    17%17%
    18%18%
  • Nausea
    10%10%
  • Upper airway infection
    10%10%
    6%6%
  • Post-menopausal bleeding
    10%10%
    3%3%
  • Sinus infection
    7%7%
  • Ovarian cyst
    7%7%
  • Back pain
    3%3%
    3%3%
  • Difficulty sleeping
    3%3%
    3%3%
  • Accidental injury
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of estradiol / norethindrone.

Activella (estradiol / norethindrone)
Placebo

People taking estradiol / norethindrone felt side effect more

People taking estradiol / norethindrone felt side effect less

No difference

Risks and Warnings for Activella (estradiol / norethindrone)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than 1 year

    If you're taking Activella (estradiol / norethindrone) and have an intact uterus, you might have a higher risk of having endometrial cancer. Vaginal bleeding after menopause can be a warning sign, so let your doctor know if you notice any unusual bleeding. Using medicines like Activella (estradiol / norethindrone) for more than a year can raise your risk. Talk to your doctor about other medicines you can take with Activella (estradiol / norethindrone) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Activella (estradiol / norethindrone)

Final section. Do you want to return to drug navigation?
Pain
  • Activella (estradiol / norethindrone) can raise your risk of blood clots, which can be very dangerous. Get medical care right away if you have pain or swelling in your legs or arms, severe headache, trouble breathing, or sudden changes in your speech or vision.