Lyrica

(pregabalin)

3.3/ 5 average rating with 66 reviewsforLyrica
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Treats pain caused by nerve damage and prevents seizures.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

Lowest price near you
  • Price before coupon
    $562.52
  • Lowest price with coupon
    $438.32
  • Savings
    22%
Quick facts about Lyrica
  • Drug class: Neurology
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
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What to expect from Lyrica, on one page

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People’s experience with Lyrica

66reviews so far. What do you think?

Downsides

  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
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What to expect from Lyrica, on one page

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How it works

Lyrica (pregabalin) is a gamma-aminobutyric acid (GABA) analog, which decreases activity at the nerve endings to relieve pain and prevent seizures.

Quick facts about Lyrica
  • Drug class: Neurology
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
  • Liquid
People’s experience with Lyrica

66reviews so far. What do you think?

Prices and coupons

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What to expect when you take Lyrica (pregabalin) for Fibromyalgia

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Dizziness
  • Drowsiness
  • Uncoordination
  • Swelling of the hands and feet
  • Blurry vision
  • Weight gain
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Side effect rates for Lyrica (pregabalin)

From 637 clinical trials of Lyrica when taken for fibromyalgia (150 mg daily)
  • Dizziness
    23%23%
    9%9%
  • Drowsiness
    13%13%
    4%4%
  • Headache
    11%11%
    12%12%
  • Blurry vision
    8%8%
    1%1%
  • Weight gain
    8%8%
    2%2%
  • Dry mouth
    7%7%
    2%2%
  • Fatigue
    5%5%
    4%4%
  • Swelling of the hands and feet
    5%5%
    2%2%
  • Constipation
    4%4%
    2%2%
  • Sinus infection
    4%4%
    4%4%
  • Increased appetite
    4%4%
    1%1%
  • Joint pain
    4%4%
    2%2%
  • Loss of focus
    4%4%
    1%1%
  • Feeling off balance
    2%2%
  • Vomiting
    2%2%
    2%2%
  • Abdominal distension
    2%2%
    1%1%
  • Chest pain
    2%2%
    1%1%
  • Fluid retention
    2%2%
    1%1%
  • Muscle spasms
    2%2%
    2%2%
  • Back pain
    2%2%
    3%3%
  • Balance disorder
    2%2%
  • Abnormal coordination
    2%2%
    1%1%
  • Partial loss of sensitivity to touch
    2%2%
    1%1%
  • Lethargy
    2%2%
  • Intense feeling of happiness
    2%2%
    1%1%
  • Anxiety
    2%2%
    1%1%
  • Depression
    2%2%
    2%2%
  • Sore throat
    2%2%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Lyrica.

Lyrica (pregabalin)
Placebo

People taking Lyrica felt side effect more

People taking Lyrica felt side effect less

No difference

Risks and Warnings for Lyrica (pregabalin)

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    • Higher risk if:
    • Starting Lyrica (pregabalin) or changing doses

    Lyrica (pregabalin) can increase the risk of suicidal thoughts or behavior. Report new or worsening symptoms of depression or unusual changes in mood or behavior to your doctor right away.

Pharmacist Q&A

Lyrica (pregabalin) questions for

Frequently Asked Questions

This medication treats fibromyalgia.

Who is this drug for?

This medication treats fibromyalgia.

Common concerns from people taking Lyrica (pregabalin)

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Price
  • Worth it
    Low hassle
    Reviewed Lyricaon 7/18/2017Cost vs sideeffects. Worried to try to switch and my pain gets out of control
    44
    Woman
    Two years or more
    Fibromyalgia
Food
  • Not worth it
    Big hassle
    Reviewed Lyricaon 1/30/2017Hide all food in the house, or you will eat it all in one day.
    54
    Man
    Nerve pain from shingles
  • Worth it
    Low hassle
    Reviewed Lyricaon 7/13/2016Start slowly and work your way up. Even experiment taking it with or without food to get rid of the initial side effects.
    45
    Woman
    Nerve pain from diabetes
Kidneys and liver
  • Requires adjustment in dose if you have lower kidney function.
Pain
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Worth it
    Big hassle
    Reviewed Lyricaon 3/7/2018Takes care of the pain but I gained 18 lbs in the first 2 weeks which I worked hard to loose. Now I can’t loose ANY weight. Terrible side effect
    47
    Woman
    A few months
    Restless leg syndrome
  • Not worth it
    Low hassle
    Reviewed Lyricaon 9/17/2017Wish I could have been told my pain wouldn't be any better, and, how about making it a lot more affordable for us. In my generation, the majority of us can't afford to pay for it and still meet our other needs.
    70
    Man
    Two years or more
    Nerve pain
  • Worth it
    Some hassle
    Reviewed Lyricaon 1/29/2017Worked well for the pain that I had in my kidney due to kidney stones. haven't experienced much side effects, haven't gained weight neither. Good medication for nerve pain.
    31
    Man
    Fibromyalgia
Sleep
  • Lyrica (pregabalin) causes drowsiness. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how this medicine affects you.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
  • Not sure
    Big hassle
    Reviewed Lyricaon 10/8/2017I’m still on it, titrating up. The jury is still out on this. The drowsiness it causes affects my life in a major way every time pain management makes an increase and I have to ride it out until my system adjusts to it. Came down with constipation a week after titrating up to 150 mg a day. I keep having back pain flares and my physical therapy is not keeping those at bay, hence the dosage increases. I will say that this drug is more tolerable for me than Gabapentin.
    36
    Woman
    A few months
    Nerve pain
  • Worth it
    Some hassle
    Reviewed Lyricaon 4/8/2017It does cause a lot of drowsiness at first, but there is adjustment to that. 2-3 hours after taking it there is drowsiness. I only take it in evening due to that.
    61
    Woman
    Two years or more
    Fibromyalgia
  • Not worth it
    Some hassle
    Reviewed Lyricaon 3/16/2017I've been on Lyrica for many years now. It has never helped my Fibromyalgia! All it does is cause drowsiness, so I only take 100mg before bedtime.
    51
    Woman
    Two years or more
    Fibromyalgia
Weight
  • Not sure
    Some hassle
    Reviewed pregabalinon 3/6/2018caused lot of weight gain
    66
    Man
    A few months
    Would rather not say
  • Not worth it
    Big hassle
    Reviewed Lyricaon 6/4/2017Weight gain is very common, I had no idea and have gained 30kgs in less than a year
    29
    Woman
    A year or so
    Nerve pain from spinal cord injury
  • Not sure
    Some hassle
    Reviewed Lyricaon 5/22/2017Horrible weight gain....30lbs! Even if it is helping with the fibro, idk because I've gotten so fat I now feel horrible about my self image and won't go anywhere. Which in turn, causes more problems. Not to mention the nasty dry mouth it gives. And watching the tv "1 eyed" because I see double gets old too. So it seems like Im much much screwed either way.
    54
    Woman
    A few months
    Fibromyalgia