Marplan

(isocarboxazid)

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Helps improve your mood.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Marplan (isocarboxazid) is an antidepressant that only recommended if other medications haven't worked.

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Quick facts about Marplan
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Marplan (isocarboxazid) is a good option for depression when other medications haven't helped.
  • Compared to similar medications, Marplan (isocarboxazid) has the least amount of side effects.
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What to expect from Marplan, on one page

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Downsides

  • You will need to avoid certain foods like cheese and aged meats while taking Marplan (isocarboxazid).
  • You should avoid consuming caffeine like coffee and soda while on this medication.
  • You have to take Marplan (isocarboxazid) twice a day, which can be hard to remember.
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What to expect from Marplan, on one page

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How it works

Marplan (isocarboxazid) is a monoamine oxidase inhibitor. It slows the breakdown of different chemicals such as epinephrine, dopamine and serotonin in your brain that help improve your mood.

Quick facts about Marplan
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Marplan (isocarboxazid) for Depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Headache
  • Dizziness
  • Anxiety
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Side effect rates for Marplan (isocarboxazid)

From 171 clinical trials of Marplan when taken for depression (< 50mg)
  • Dizziness
    28%28%
    14%14%
  • Headache
    15%15%
    13%13%
  • Dry mouth
    9%9%
    4%4%
  • Constipation
    7%7%
    6%6%
  • Nausea
    6%6%
    2%2%
  • Nightmares
    5%5%
  • Drowsiness
    4%4%
  • Changes in blood pressure
    4%4%
    1%1%
  • Insomnia
    4%4%
    4%4%
  • Tremors
    4%4%
  • Anxiety
    2%2%
    1%1%
  • Chills
    2%2%
  • Forgetfullness
    2%2%
    1%1%
  • Hyperactivity
    2%2%
  • Sluggishness
    2%2%
  • Sedation
    2%2%
    1%1%
  • Fainting
    2%2%
  • Increased sweating
    2%2%
  • Feeling of heaviness
    2%2%
  • Racing heart rate
    2%2%
    1%1%
  • Diarrhea
    2%2%
    1%1%
  • Impotence
    2%2%
  • Increased urination
    2%2%
    1%1%
  • Muscle spasms
    2%2%
  • Burning feeling in hands and feet
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Marplan.

Marplan (isocarboxazid)
Placebo

People taking Marplan felt side effect more

People taking Marplan felt side effect less

No difference

Risks and Warnings for Marplan (isocarboxazid)

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    • Higher risk if:
    • › People under age 24

    Taking Marplan (isocarboxazid) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you feel like you want to hurt yourself while taking Marplan (isocarboxazid), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Marplan (isocarboxazid)

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Alcohol
  • If you're taking medicines that can make you sleepy, like opioids or benzodiazepines, or drink more than 4 alcoholic drinks a day, talk to your doctor before you start taking Marplan (isocarboxazid). Marplan (isocarboxazid) can make you sleepier and slow your breathing down.
  • Limit the amount of alcohol and caffeine you consume while taking Marplan (isocarboxazid).
Food
  • Certain foods can cause your blood pressure to go up while you're taking Marplan (isocarboxazid). This can be very dangerous if you already have high blood pressure. This includes fermented or smoked foods like cheese, alcohol, soy sauce, fish sauce, pickles and dried sausage. You'll need to limit the amount of these foods you consume. Talk to your doctor or pharmacist if you have questions.
  • You'll have to limit certain foods in your diet while taking Marplan (isocarboxazid) because they can raise your blood pressure.
  • You will need to avoid certain foods like cheese and aged meats while taking Marplan (isocarboxazid).