Otrexup

(methotrexate)

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Reduces inflammation and cell replication.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Otrexup (methotrexate) is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.

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    $475.26
Quick facts about methotrexate
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (methotrexate)

Upsides

  • Otrexup (methotrexate) is available as an affordable generic form.
  • Otrexup (methotrexate) comes as a tablet, an injection that you give yourself, or an infusion that you get in the doctor's office or infusion center.
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What to expect from methotrexate, on one page

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Downsides

  • You may need frequent blood tests for monitoring when taking Otrexup (methotrexate).
  • Otrexup (methotrexate) can cause serious birth defects so women should avoid getting pregnant for at least 6 month and men 3 months after taking it.
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
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What to expect from methotrexate, on one page

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How it works

Otrexup (methotrexate) blocks the growth of new cancer cells and reduces inflammation.

Quick facts about methotrexate
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (methotrexate)

Used for

Dosage forms

  • Pill
  • Injection
  • Liquid
Tried methotrexate? Write a review!

Prices and coupons

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What to expect when you take Otrexup (methotrexate) for Psoriasis

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Burning sensation at psoriasis skin lesions
  • Increased sensitivity to light
  • Hair loss
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Side effect rates for Otrexup (methotrexate)

  • Abnormal liver function tests
    14%14%
  • Nausea, vomiting, diarrhea
    11%11%
  • Mouth inflammation and sores
    2%2%
  • Low white blood count
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of methotrexate.

Otrexup (methotrexate)
Placebo

People taking methotrexate felt side effect more

People taking methotrexate felt side effect less

No difference

Risks and Warnings for Otrexup (methotrexate)

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  • Otrexup (methotrexate) affects your bone marrow and causes irregularities in the production of new blood cells. If you're taking Otrexup (methotrexate), you’ll need to have your blood drawn regularly to monitor for any side effects.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Otrexup (methotrexate)

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Interactions
  • Can interfere with how other medicines work. Make sure you tell your doctor all of the medicines you take, including over-the-counter medicines and supplements.
Alcohol
  • While on Otrexup (methotrexate), you should avoid alcohol and staying out in the sun for too long.
Food
  • Worth it
    Some hassle
    Reviewed methotrexateon 2/25/2018Take it at night, take it with food. Makes you tired on the next day, but then gets better. Some nausea sometimes.
    37
    Woman
    A year or so
    Would rather not say
Kidneys and liver
  • If you have kidney disease, fluid in the abdomen or other conditions that affect how your body clears Otrexup (methotrexate) from your system, you may be at higher risk for having harmful side effects. Your doctor will monitor your symptoms and blood tests very closely while on Otrexup (methotrexate).
Pain
  • Call your doctor immediately if you develop diarrhea or mouth sores. This could be a toxic reaction to Otrexup (methotrexate) and your doctor will need to stop the medication or prescribe an antidote.
Sleep
  • Not worth it
    Low hassle
    Reviewed methotrexateon 4/8/2017Take before bed to sleep through most side effects. Took for 6 months with not much relief and lots of hair loss. Even with adding folic acid daily.
    33
    Woman
    A few months
    Rheumatoid arthritis (severe)