Relistor

(methylnaltrexone)

Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Treats opioid-induced constipation.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

When laxatives aren't enough, Relistor (methylnaltrexone) can help treat constipation caused by opioids without affecting opioid pain relief.

Lowest price near you
  • Lowest price with coupon
    $1632.11
Quick facts about Relistor
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Relistor (methylnaltrexone) relieves your constipation with an easy to take once daily dose.
  • It’s an effective option when other constipation medicines don’t work for you.
  • Fast relief allows you to predict when your bowel movement will occur, allowing you to plan your day.
  • You might be eligible for a savings card that lowers your copay. Talk to your doctor or pharmacist.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Relistor, on one page

Download Fact Sheet
Tried Relistor? Write a review!

Downsides

  • Relistor (methylnaltrexone) is generally reserved for more severe constipation. Your doctor will have you try other constipation medications first.
  • It’s more expensive than other medicines used to treat constipation.
  • Let your doctor know what other medications you are currently taking as certain drugs can interact with Relistor (methylnaltrexone).
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Relistor, on one page

Download Fact Sheet
How it works

Opioids act on certain sites in the gut that cause constipation. Relistor (methylnaltrexone) works by blocking the effects of opioids in the gut.

Quick facts about Relistor
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Opioid-induced constipation

Dosage forms

  • Pill
  • Injection
Tried Relistor? Write a review!

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 90 (150mg) tablets of Relistor near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Relistor (methylnaltrexone) for Opioid-induced constipation

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Stomach pain
  • Passing gas
  • Nausea
  • Diarrhea
  • Headache
  • Sweating
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Relistor (methylnaltrexone)

From 288 clinical trials of Relistor when taken for oic from advanced illness (0.075, 0.15, and 0.3 mg/kg subcutaneously once daily)
  • Stomach pain
    28%28%
    10%10%
  • Passing gas
    13%13%
    6%6%
  • Nausea
    12%12%
    5%5%
  • Dizziness
    7%7%
    2%2%
  • Diarrhea
    6%6%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Relistor.

Relistor (methylnaltrexone)
Placebo

People taking Relistor felt side effect more

People taking Relistor felt side effect less

No difference

Risks and Warnings for Relistor (methylnaltrexone)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • History of bowel or stomach problems

    Relistor (methylnaltrexone) can cause a hole in your stomach or intestines if you currently have bowel or stomach problems, such as stomach ulcer, Crohn's disease, Ogilvie’s syndrome, or stomach cancer. Talk to your doctor or go to the emergency room right away if you experience worsening or severe stomach pain that won't go away, vomiting, or fever, as this can be life-threatening. Your doctor might need to switch you to a different medication.

Common concerns from people taking Relistor (methylnaltrexone)

Final section. Do you want to return to drug navigation?
Price
  • Discontinue Relistor (methylnaltrexone) and speak to your doctor right away if you experience severe diarrhea that will not stop.
Kidneys and liver
  • Relistor (methylnaltrexone) is processed by the kidney and liver. Bad liver function can expose you to higher levels of Relistor (methylnaltrexone) in the body and may raise your risk of side effects. Tell your doctor if you have liver problems. Your doctor will adjust Relistor (methylnaltrexone)'s dose according to your liver function.
  • Relistor (methylnaltrexone) is processed by the kidney and liver. Bad kidney function can expose you to higher levels of Relistor (methylnaltrexone) in the body and may raise your risk of side effects. Tell your doctor if you have kidney problems. Your doctor will adjust Relistor (methylnaltrexone)'s dose according to your kidney function.