Movantik

(naloxegol)

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Relieves constipation caused by opioid pain relievers.

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Our bottom line

Movantik (naloxegol) is a good option for treating constipation due to the use of opioids. However, it can cause side effects that make you feel like you are going through opioid withdrawal.

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    $351.17
Quick facts about Movantik
  • Drug class: gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Is a good option if traditional laxatives have not worked for you.
  • Take Movantik (naloxegol) only once a day.
  • Compared to alternatives, this medicine doesn't affect your heart.
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What to expect from Movantik, on one page

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Downsides

  • Side effects of Movantik (naloxegol), including withdrawal and loss of pain control, may be worse in people taking certain opiates, such as methadone.
  • More expensive than traditional laxatives. There is no generic available.
  • Need to take this medicine on an empty stomach or it won't work as well.
  • You may have to take a lower dose of Movantik (naloxegol) if you have kidney problems, which may be less effective or cause more side effects.
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What to expect from Movantik, on one page

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How it works

Movantik (naloxegol) blocks opioids from interacting with receptors in your intestines that cause constipation, so you are able to go easier and more often.

Quick facts about Movantik
  • Drug class: gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Opioid induced constipation

Dosage forms

  • Pill
Tried Movantik? Write a review!

Prices and coupons

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What to expect when you take Movantik (naloxegol) for Opioid induced constipation

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  • First few hoursHours
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  • Effectiveness
  • Starts to kick in
    Full effects
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  • Possible side effects
  • Abdominal pain
  • Headache
  • Diarrhea
  • Gas
  • Excess sweating
  • Vomiting
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Side effect rates for Movantik (naloxegol)

From 890 clinical trials of Movantik when taken for opioid induced constipation (movantik 25mg)
  • Abdominal pain
    21%21%
    7%7%
  • Diarrhea
    9%9%
    5%5%
  • Nausea
    8%8%
    5%5%
  • Gas
    6%6%
    3%3%
  • Vomiting
    5%5%
    4%4%
  • Headache
    4%4%
    3%3%
  • Excess sweating
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Movantik.

Movantik (naloxegol)
Placebo

People taking Movantik felt side effect more

People taking Movantik felt side effect less

No difference

Risks and Warnings for Movantik (naloxegol)

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    • Higher risk if:
    • Methadone use

    Although rare, Movantik (naloxegol) can cause opioid withdrawal symptoms (chills, diarrhea, abdominal pain, anxiety, irritability, and yawning) and reduced pain relief, especially if you are on methadone. Talk to your doctor if you experience any of these symptoms since your dose of opioids might have to change.

Common concerns from people taking Movantik (naloxegol)

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Food
  • Take Movantik (naloxegol) in the morning on an empty stomach 1 hour before breakfast or 2 hours after breakfast.
Pain
  • Movantik (naloxegol) can cause severe abdominal pain and/or diarrhea within a few days of starting this drug. The chance of this happening is higher if you are taking the 25mg dose. Let your doctor know right away if you experince this. You may need to be switched to a lower dose or different medication.
  • Side effects of Movantik (naloxegol), including withdrawal and loss of pain control, may be worse in people taking certain opiates, such as methadone.