Symproic

(naldemedine)

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Relieves constipation caused by opiate pain medications.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Symproic (naldemedine) quickly relieves constipation caused by opioids without affecting pain relief, but it can be expensive.

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  • Price before coupon
    $471.67
  • Lowest price with coupon
    $375.40
  • Savings
    20%
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Quick facts about Symproic
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Symproic (naldemedine) is a good option if traditional laxatives have not worked for you.
  • You only have to take Symproic (naldemedine) once a day.
  • Symproic (naldemedine) doesn't affect how opioids treat pain.
  • It works much faster than most other laxatives.
  • It does not have to be dose adjusted if you have kidney problems.
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What to expect from Symproic, on one page

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Downsides

  • Symproic (naldemedine) is not available as a cheaper generic form.
  • It is more expensive than traditional axatives.
  • This medication is not a good option if you have severe liver problems.
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What to expect from Symproic, on one page

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How it works

Symproic (naldemedine) blocks opioids from interacting with receptors in your intestines that cause constipation, thereby making it easier for you to pass stool.

Quick facts about Symproic
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Opioid-induced constipation

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Symproic (naldemedine) for Opioid-induced constipation

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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
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  • Possible side effects
  • Stomach pain
  • Diarrhea
  • Nausea
  • Stomach flu
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Side effect rates for Symproic (naldemedine)

From 1088 clinical trials of Symproic when taken for opioid-induced constipation (0.2mg once daily)
  • Stomach pain
    8%8%
    2%2%
  • Diarrhea
    7%7%
    2%2%
  • Nausea
    4%4%
    2%2%
  • Stomach flu
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Symproic.

Symproic (naldemedine)
Placebo

People taking Symproic felt side effect more

People taking Symproic felt side effect less

No difference

Risks and Warnings for Symproic (naldemedine)

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  • Symproic (naldemedine) can cause opioid withdrawal symptoms, such as chills, diarrhea, stomach pain, anxiety, irritability, nausea, and vomiting. Moreover, it can also cause reduced pain relief. Talk to your doctor if you experience any of these symptoms since your dose of opioids might have to be changed.

Common concerns from people taking Symproic (naldemedine)

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Food
  • Take Symproic (naldemedine) with or without food.
Kidneys and liver
  • It does not have to be dose adjusted if you have kidney problems.
  • This medication is not a good option if you have severe liver problems.