Symproic

(naldemedine)

Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Relieves constipation caused by opiate pain medications.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Symproic (naldemedine) quickly relieves constipation caused by opioids without affecting pain relief, but it can be expensive.

Lowest price near you
  • Price before coupon
    $444.23
  • Lowest price with coupon
    $335.45
  • Savings
    24%
Find instant savings
Quick facts about Symproic
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Symproic (naldemedine) is a good option if traditional laxatives have not worked for you.
  • You only have to take Symproic (naldemedine) once a day.
  • Symproic (naldemedine) doesn't affect how opioids treat pain.
  • It works much faster than most other laxatives.
  • It does not have to be dose adjusted if you have kidney problems.
Get our free fact sheet

What to expect from Symproic, on one page

Download Fact Sheet
Tried Symproic? Write a review!

Downsides

  • Symproic (naldemedine) is not available as a cheaper generic form.
  • It is more expensive than traditional axatives.
  • This medication is not a good option if you have severe liver problems.
Get our free fact sheet

What to expect from Symproic, on one page

Download Fact Sheet
How it works

Symproic (naldemedine) blocks opioids from interacting with receptors in your intestines that cause constipation, thereby making it easier for you to pass stool.

Quick facts about Symproic
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Opioid-induced constipation

Dosage forms

  • Pill
Tried Symproic? Write a review!

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 30 (0.2mg) tablets of Symproic near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Symproic (naldemedine) for Opioid-induced constipation

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Stomach pain
  • Diarrhea
  • Nausea
  • Stomach flu
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Symproic (naldemedine)

From 1088 clinical trials of Symproic when taken for opioid-induced constipation (0.2mg once daily)
  • Stomach pain
    8%8%
    2%2%
  • Diarrhea
    7%7%
    2%2%
  • Nausea
    4%4%
    2%2%
  • Stomach flu
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Symproic.

Symproic (naldemedine)
Placebo

People taking Symproic felt side effect more

People taking Symproic felt side effect less

No difference

Risks and Warnings for Symproic (naldemedine)

Skip risks section. Skip to common concerns section.

  • Symproic (naldemedine) can cause opioid withdrawal symptoms, such as chills, diarrhea, stomach pain, anxiety, irritability, nausea, and vomiting. Moreover, it can also cause reduced pain relief. Talk to your doctor if you experience any of these symptoms since your dose of opioids might have to be changed.

Common concerns from people taking Symproic (naldemedine)

Final section. Do you want to return to drug navigation?
Food
  • Take Symproic (naldemedine) with or without food.
Kidneys and liver
  • It does not have to be dose adjusted if you have kidney problems.
  • This medication is not a good option if you have severe liver problems.