Nardil

(phenelzine)

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Stabilizes your mood.

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Our bottom line

Nardil (phenelzine) is not a first choice for treating depression, but it can be good if other medicines haven't worked. It can interact with a lot of medicines, and you have to avoid certain foods and alcohol.

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Quick facts about phenelzine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (phenelzine)

Upsides

  • Available in generic.
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Downsides

  • Not a recommended first or second choice for depression because of the side effects and diet restrictions.
  • You'll need to restrict your diet because your blood pressure can get very high.
  • If you're switched to another antidepressant from Nardil (phenelzine), you'll have to wait at least 14 days before you can start, otherwise it can be very dangerous.
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What to expect from phenelzine, on one page

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How it works

Nardil (phenelzine) is a monoamine oxidase inhibitor. It raises the amount of certain chemicals in your body that are thought to regulate mood, such as norepinephrine, dopamine, and serotonin.

Quick facts about phenelzine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (phenelzine)

Used for

Dosage forms

  • Pill
Tried phenelzine? Write a review!

Prices and coupons

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What to expect when you take Nardil (phenelzine) for Depression

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Higher risk of suicide
  • Dizziness
  • Changes in sleep
  • Weight gain
  • Constipation
  • Lower sex drive
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Side effect rates for Nardil (phenelzine)

Risks and Warnings for Nardil (phenelzine)

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    • Higher risk if:
    • People under age 24

    Taking Nardil (phenelzine) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking it. If you or your child feel like they want to hurt themselves while taking Nardil (phenelzine), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Nardil (phenelzine)

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Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for phenelzine
NUnknown
Alcohol
  • Eating certain foods or drinking beer or wine while taking Nardil (phenelzine) can cause your blood pressure to become dangerously high. Talk to your doctor or go to the emergency room right away if you get a very bad headache, changes in your heart rate, neck stiffness or soreness, or nausea and vomiting.
  • Avoid alcohol and limit the amount of caffeine you take if you take Nardil (phenelzine).
Weight
  • Nardil (phenelzine) can cause weight gain.