Nuedexta

(dextromethorphan / quinidine)

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Lowers the number of episodes of sudden, frequent, uncontrollable crying or laughing that doesn't match how you feel.

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Our bottom line

Nuedexta (dextromethorphan / quinidine) is the only medicine approved for pseudobulbar affect. It is only available as a brand name, so it can have an expensive copay.

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    $1098.86
Quick facts about Nuedexta
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Nuedexta (dextromethorphan / quinidine) is recommended as a first choice medicine for pseudobulbar affect.
  • Compared to other medicines used to treat this condition, Nuedexta (dextromethorphan / quinidine) has fewer and milder side effects.
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What to expect from Nuedexta, on one page

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Downsides

  • Nuedexta (dextromethorphan / quinidine) is only available as a brand name, so it can have an expensive copay.
  • Nuedexta (dextromethorphan / quinidine) can cause dizziness and might make you more likely to fall.
  • Nuedexta (dextromethorphan / quinidine) can cause changes in heartbeat. If you’ve had heart rhythm problems or heart disease, it might not be a good medicine for you.
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What to expect from Nuedexta, on one page

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How it works

Nuedexta (dextromethorphan / quinidine) is a combination of 2 medicines: dextromethorphan and quinidine. It's not clear how dextromethorphan helps maintain your mood. Quinidine slows the breakdown of dextromethorphan in the body.

Quick facts about Nuedexta
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Pseudobulbar affect
  • Agitation/aggression in Alzheimer's disease

Dosage forms

  • Pill
Tried Nuedexta? Write a review!

Prices and coupons

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What to expect when you take Nuedexta (dextromethorphan / quinidine) for Pseudobulbar affect

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  • First few hoursHours
    First few daysDays
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
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  • Possible side effects
  • Allergic reactions
  • Liver damage
  • Heart problems
  • Dizziness
  • Diarrhea
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Side effect rates for Nuedexta (dextromethorphan / quinidine)

From 216 clinical trials of Nuedexta when taken for pseudobulbar affect (dextromethorphan 20 mg/ quinidine sulfate 10 mg twice daily)
  • Diarrhea
    13%13%
    6%6%
  • Dizziness
    10%10%
    5%5%
  • Cough
    5%5%
    2%2%
  • Vomiting
    5%5%
    1%1%
  • Weakness
    5%5%
    2%2%
  • Swelling in arms and legs
    5%5%
    1%1%
  • Urinary tract infections
    4%4%
    1%1%
  • Flu
    4%4%
    1%1%
  • Liver damage
    3%3%
  • Gas
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Nuedexta.

Nuedexta (dextromethorphan / quinidine)
Placebo

People taking Nuedexta felt side effect more

People taking Nuedexta felt side effect less

No difference

Risks and Warnings for Nuedexta (dextromethorphan / quinidine)

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    • Higher risk if:
    • Allergy to quinine or mefloquine

    Rare life-threatening allergic reactions have been reported with quinidine, a component of Nuedexta (dextromethorphan / quinidine). This is more common if you're allergic to quinine or mefloquine. If you suddenly have a high fever, chills, nausea or vomiting, call your doctor right away and stop taking it.

Common concerns from people taking Nuedexta (dextromethorphan / quinidine)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Nuedexta
CWeigh risks vs. benefits
Kidneys and liver
  • Hepatitis and liver damage have been reported rarely in people who've taken Nuedexta (dextromethorphan / quinidine). This usually happens in the first few weeks. Call your doctor right away if you suddenly develop a high fever and you haven't been sick.