Oleptro

(Trazodone)

●●●●●
3.6/ 5 average rating with 59 reviewsforOleptro
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Improves mood and helps you sleep.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.

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Quick facts about Oleptro
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (trazodone)

Upsides

  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
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What to expect from Oleptro, on one page

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People’s experience with Oleptro

59reviews so far. What do you think?

Downsides

  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
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What to expect from Oleptro, on one page

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How it works

Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.

Quick facts about Oleptro
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (trazodone)

Used for

Dosage forms

  • Pill
  • Extended release
People’s experience with Oleptro

59reviews so far. What do you think?

Prices and coupons

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What to expect when you take Oleptro (Trazodone) for Depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Sleepiness
  • Headache
  • Dizziness
  • Dry mouth
  • Stomach problems
  • Tiredness
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Oleptro (Trazodone)

From 315 clinical trials of Oleptro when taken for depression
  • Somnolence/Sedation
    46%46%
    19%19%
  • Drowsiness
    41%41%
    20%20%
  • Dry Mouth
    34%34%
    20%20%
  • Headache
    33%33%
    27%27%
  • Dizziness/Lightheadedness
    28%28%
    15%15%
  • Dry mouth
    25%25%
    13%13%
  • Dizziness
    25%25%
    12%12%
  • Nausea
    21%21%
    13%13%
  • Headache
    20%20%
    16%16%
  • Blurred Vision
    15%15%
    4%4%
  • Fatigue
    15%15%
    8%8%
  • Nausea/Vomiting
    13%13%
    10%10%
  • Diarrhea
    9%9%
    11%11%
  • Constipation
    8%8%
    6%6%
  • Skin Condition/Edema
    7%7%
    1%1%
  • Fatigue
    6%6%
    3%3%
  • Weight Loss
    6%6%
    3%3%
  • Nasal/Sinus Congestion
    6%6%
    3%3%
  • Abdominal/Gastric Disorder
    6%6%
    4%4%
  • Diarrhea
    5%5%
    2%2%
  • Syncope
    5%5%
    1%1%
  • Musculoskeletal Aches/Pains
    5%5%
    3%3%
  • Tremors
    5%5%
    4%4%
  • Nightmares/Vivid Dreams
    5%5%
    6%6%
  • Weight Gain
    5%5%
    2%2%
  • Back pain
    5%5%
    3%3%
  • Vision blurred
    5%5%
  • Sexual dysfunction
    5%5%
    2%2%
  • Hypotension
    4%4%
  • Incoordination
    2%2%
  • Ejaculation disorders
    2%2%
  • Decreased libido
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Oleptro.

Oleptro (Trazodone)
Placebo

People taking Oleptro felt side effect more

People taking Oleptro felt side effect less

No difference

Risks and Warnings for Oleptro (Trazodone)

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    • Higher risk if:
    • › Age 24 years or younger

    Oleptro (Trazodone) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Oleptro (Trazodone) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Oleptro (Trazodone)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Oleptro
CWeigh risks vs. benefits
Alcohol
  • Worth it
    Worked so-so
    Some hassle
    Reviewed Oleptroon 8/12/2017❗️DO NOT MIX WITH ALCOHOL. 🍸
    26
    Woman
    A month or so
    Insomnia
Sleep
  • Worth it
    Worked well
    Low hassle
    Reviewed trazodoneon 12/10/2020.25 mg. and sleep like a baby, with no side effects.
    66
    Man
    Two years or more
    Insomnia
  • Not worth it
    Didn’t work
    Low hassle
    Reviewed trazodoneon 11/8/2019Did not help me sleep lorazepam worked better.
    57
    Man
    A month or so
    Insomnia
  • Worth it
    Worked well
    Low hassle
    Reviewed OleptroDrowsy in morning
    58
    Woman
    Two years or more
    I took it for: insomnia