Onfi

(clobazam)

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Treats seizures caused by Lennox-Gastaut syndrome.

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Our bottom line

Onfi (clobazam) can be used to treat seizures caused by Lennox-Gastaut syndrome, but you have to take it with your other medicines.

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    $1644.48
Quick facts about Onfi
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Onfi (clobazam) comes in liquid form and may be helpful if you have trouble swallowing pills.
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What to expect from Onfi, on one page

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Downsides

  • Approved to treat only seizures from Lennox-Gastaut syndrome.
  • Combining with other sedatives may cause extreme drowsiness.
  • Stopping this medicine may result in more frequent seizures for the first few weeks.
  • Should only use Onfi (clobazam) with other medications to help control seizures.
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What to expect from Onfi, on one page

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How it works

It's not clear how Onfi (clobazam) stops seizures, but it works with the brain to stop signals that can start seizures.

Quick facts about Onfi
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Lennox-Gastaut syndrome

Dosage forms

  • Pill
  • Liquid
Tried Onfi? Write a review!

Prices and coupons

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What to expect when you take Onfi (clobazam) for Lennox-Gastaut syndrome

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Drowsiness or sleepiness
  • Physical dependence
  • Serious allergic reaction
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Side effect rates for Onfi (clobazam)

From 238 clinical trials of Onfi when taken for lennox-gastaut syndrome
  • Drowsiness or sleepiness
    26%26%
    15%15%
  • Fever
    13%13%
    3%3%
  • Upper respiratory tract infection
    12%12%
    10%10%
  • Lack of motivation
    10%10%
    5%5%
  • Drooling
    9%9%
    3%3%
  • Difficulty controlling movements
    9%9%
    3%3%
  • Aggression
    8%8%
    5%5%
  • Vomiting
    7%7%
    5%5%
  • Irritability
    7%7%
    5%5%
  • Constipation
    5%5%
  • Fatigue
    5%5%
    2%2%
  • Insomnia
    5%5%
    2%2%
  • Cough
    5%5%
  • Pneumonia
    4%4%
    2%2%
  • Hyperactivity
    4%4%
    3%3%
  • Decreased appetite
    3%3%
    3%3%
  • Increased appetite
    3%3%
  • Changes in speech
    3%3%
  • Difficulty swallowing
    2%2%
  • Urinary tract infection (UTI)
    2%2%
  • Bronchitis
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Onfi.

Onfi (clobazam)
Placebo

People taking Onfi felt side effect more

People taking Onfi felt side effect less

No difference

Risks and Warnings for Onfi (clobazam)

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    • Higher risk if:
    • Taken together with opioids
    • Taken together with benzodiazepines
    • History of drug abuse

    If you take other medicines for pain called opioids or benzodiazepines for anxiety, talk to your doctor first before starting Onfi (clobazam). Taking any of these medicines with Onfi (clobazam) can make it difficult to breathe, which can be very dangerous.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Onfi (clobazam)

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Pain
  • If you take other medicines for pain called opioids or benzodiazepines for anxiety, talk to your doctor first before starting Onfi (clobazam). Taking any of these medicines with Onfi (clobazam) can make it difficult to breathe, which can be very dangerous.
Sleep
  • Can make you feel sleepy.
  • Combining with other sedatives may cause extreme drowsiness.