Onzetra

(sumatriptan)

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Treats migraine headaches.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.

Lowest price near you
  • Price before coupon
    $49.06
  • Lowest price with coupon
    $12.81
    74% savings
Quick facts about Onzetra
  • Drug class: neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
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What to expect from Onzetra, on one page

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Tried Onzetra? Write a review!

Downsides

  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
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What to expect from Onzetra, on one page

Download Fact Sheet
How it works

Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.

Quick facts about Onzetra
  • Drug class: neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Nasal powder
Tried Onzetra? Write a review!

Prices and coupons

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What to expect when you take Onzetra (sumatriptan) for Migraine

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  • First few hoursHours
    First few daysDays
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    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Heart attack or stroke
  • Medication overuse headache
  • Serotonin syndrome
  • Higher blood pressure
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Side effect rates for Onzetra (sumatriptan)

From 301 clinical trials of Onzetra when taken for migraine
  • Changes in taste
    20%20%
    3%3%
  • Discomfort in the nose
    11%11%
    1%1%
  • Runny nose
    5%5%
    2%2%
  • Stuffy nose
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Onzetra.

Onzetra (sumatriptan)
Placebo

People taking Onzetra felt side effect more

People taking Onzetra felt side effect less

No difference

Risks and Warnings for Onzetra (sumatriptan)

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    • Higher risk if:
    • Heart disease
    • History of chest pain
    • Uncontrolled high blood pressure

    People who have heart disease or a history of chest pain shouldn't take Onzetra (sumatriptan) because heart attacks have happened after people with heart disease took this medicine. This can feel like pain in the chest, jaw, neck, or throat. Talk to your doctor first to see if you can take Onzetra (sumatriptan).