Opana

(oxymorphone)

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Treats pain.

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Our bottom line

Opana (oxymorphone) treats severe pain, but prolonged use can lead to dependence, tolerance, and possibly addiction.

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Quick facts about Opana
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (oxymorphone)

Upsides

  • Generic is available, making Opana (oxymorphone) an affordable option.
  • Available in both short-acting and long-acting formulations.
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What to expect from Opana, on one page

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Downsides

  • Opana (oxymorphone) is a powerful pain reliever, which can be dangerous at high doses or when taken for a long time.
  • Opana (oxymorphone) needs to be taken on an empty stomach, which may be inconvenient.
  • People with kidney or liver problems need to use extra caution with Opana (oxymorphone), since these conditions increases the likelihood of an overdose.
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What to expect from Opana, on one page

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How it works

Opana (oxymorphone) is an opioid that works on the brain to reduce your perception of pain.

Quick facts about Opana
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (oxymorphone)

Used for

  • Pain
  • Severe, chronic pain

Dosage forms

  • Pill
  • Extended-release pill
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Prices and coupons

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What to expect when you take Opana (oxymorphone) for Pain

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Physical dependence
  • Constipation
  • Sleepiness
  • Nausea
  • Dizziness
  • Itching
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Side effect rates for Opana (oxymorphone)

From 1720 clinical trials of Opana when taken for pain
  • Nausea
    33%33%
    13%13%
  • Constipation
    28%28%
    13%13%
  • Dizziness
    18%18%
    8%8%
  • Sleepiness
    17%17%
    2%2%
  • Vomiting
    16%16%
    4%4%
  • Itching
    15%15%
    8%8%
  • Headache
    12%12%
    6%6%
  • Increased sweating
    9%9%
    9%9%
  • Dry mouth
    6%6%
  • Sedation
    6%6%
    8%8%
  • Diarrhea
    4%4%
    6%6%
  • Difficulty sleeping
    4%4%
    2%2%
  • Fatigue
    4%4%
    1%1%
  • Decreased appetite
    3%3%
  • Stomach pain
    3%3%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Opana.

Opana (oxymorphone)
Placebo

People taking Opana felt side effect more

People taking Opana felt side effect less

No difference

Risks and Warnings for Opana (oxymorphone)

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    • Higher risk if:
    • › Taking more than the prescribed dose
    • › Long-term use
    • › History of drug abuse
    • › Younger age

    If taken regularly for a long time, Opana (oxymorphone) can cause physical dependence and tolerance. This means that you may need larger doses to achieve the same pain relief, and experience withdrawal symptoms if the medicine is suddenly stopped. Do not take more than what is prescribed and talk to your doctor about alternatives if this is a concern.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Opana (oxymorphone)

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Kidneys and liver
  • People with kidney or liver problems need to use extra caution with Opana (oxymorphone), since these conditions increases the likelihood of an overdose.
Pain
  • Worth it
    Worked well
    Low hassle
    Reviewed oxymorphoneon 11/23/2020I have been on every pain medecine under the sun. And the o ky thing that works around the clock is opana or generic oxymorphone!I have a pimched ciatic nerve and my L5 and right shoulder is really messed up. Only meds that work are the opana instant release.
    37
    Man
    Two years or more
    Severe, chronic pain
  • Worth it
    Worked well
    Some hassle
    Reviewed Opanaon 9/1/2017Yes; over the years I've tried everything for my chronic pain and found it to work better than any other medication. It's just a shame people abuse it and make it look bad for everyone!!!
    63
    Man
    Two years or more
    Chronic (Severe)
Sleep
  • Mixing alcohol and Opana (oxymorphone) can result in excessive drowsiness and potentially fatal overdose. Avoid alcoholic beverages while taking Opana (oxymorphone).