Orap

(pimozide)

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Treats tics that happen with Tourette syndrome.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Orap (pimozide) can be used for Tourette's, but your doctor will try other medicines first because of the side effects.

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  • Price before coupon
    $148.23
  • Lowest price with coupon
    $61.40
    59% savings
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Quick facts about Orap
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pimozide)

Upsides

  • Orap (pimozide) is available as a generic.
  • There are programs available that can make Orap (pimozide) less expensive.
  • Orap (pimozide) is approved for children and adults.
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What to expect from Orap, on one page

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Downsides

  • Orap (pimozide) is not a first choice for Tourette syndrome, and it has to be used with your other medicines.
  • You're more likely to have problems with your movements.
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What to expect from Orap, on one page

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How it works

Orap (pimozide) is a typical antipsychotic. It lowers levels of dopamine in the brain, but researchers don't know how that helps treat Tourette syndrome.

Quick facts about Orap
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pimozide)

Used for

Dosage forms

  • Pill
Tried Orap? Write a review!

Prices and coupons

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What to expect when you take Orap (pimozide) for Tourette syndrome

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
  • Higher risk of infection
  • Sleepiness
  • Higher risk of seizures
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Side effect rates for Orap (pimozide)

From 40 clinical trials of Orap when taken for tourette syndrome
  • Sleepiness
    70%70%
    25%25%
  • Weakness
    40%40%
  • Difficulty using muscles
    40%40%
  • Drowsiness
    35%35%
  • Changes in behavior
    25%25%
  • Sleepiness
    25%25%
  • Changes in behavior
    22%22%
  • Dry mouth
    20%20%
    5%5%
  • Constipation
    20%20%
    10%10%
  • Vision changes
    20%20%
  • Changes in focusing in the eyes
    20%20%
  • Muscle tightness
    15%15%
  • Unable to get or maintain an erection
    15%15%
  • Weakness
    14%14%
  • Stooped posture
    10%10%
  • Trouble sleeping
    10%10%
    10%10%
  • Rigidity
    10%10%
  • Speech problems
    10%10%
  • Depression
    10%10%
    15%15%
  • Increased salivation
    6%6%
  • Nervousness
    6%6%
  • Headache
    5%5%
    10%10%
  • Diarrhea
    5%5%
  • Thirst
    5%5%
  • Increased appetite
    5%5%
  • Changes in handwriting
    5%5%
  • Nervousness
    5%5%
  • Changes in taste
    5%5%
  • Light sensitivity in the eyes
    5%5%
  • Headache
    3%3%
  • Trouble swallowing
    3%3%
  • Muscle pain
    3%3%
  • Abnormal dreams
    3%3%
  • Muscle spasms, general
    3%3%
  • Muscle spasms in the neck
    3%3%
  • Skin rashes
    3%3%
  • Vision changes
    3%3%
  • Abnormal echocardiogram
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Orap.

Orap (pimozide)
Placebo

People taking Orap felt side effect more

People taking Orap felt side effect less

No difference

Risks and Warnings for Orap (pimozide)

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  • Some people have noticed changes in being able to control movements while on Orap (pimozide). This can be permanent if it's not taken care of right away. Call your doctor right away if this happens.

Common concerns from people taking Orap (pimozide)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Orap
CWeigh risks vs. benefits
Alcohol
  • Don't have grapefruit or drink alcohol while taking Orap (pimozide).
Sleep
  • People have complained of sleepiness when starting Orap (pimozide). This usually goes away after a few days to weeks. Don't drive or do anything that requires concentration until you know how it affects you.
  • Orap (pimozide) can make you feel sleepy, so don't drive or do anything requiring concentration until you know how it affects you.