3.0/ 5 average rating with 52 reviewsforOgen
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Our bottom line

Ogen (Estropipate) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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Quick facts about Ogen
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (estropipate)


  • Available as a generic, which can be less expensive than other estrogen pills.
  • Ogen (Estropipate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
People’s experience with Ogen

52reviews so far. What do you think?


  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Ogen (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
How it works

Ogen (Estropipate) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.

Quick facts about Ogen
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (estropipate)

Used for

  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen

Dosage forms

  • Pill
People’s experience with Ogen

52reviews so far. What do you think?

Prices and coupons

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Side effect rates for Ogen (Estropipate)

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These are side effects of Ogen (Estropipate) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Ogen (Estropipate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Ogen (Estropipate)

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Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Ogen
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Worth it
    Low hassle
    Reviewed Ogenon 4/30/2017had a hysterectomy at 60 yrs was on premarin 0.3 for 20 years could no longer afford the price so im doing 0.75 every other day ..cannot take calcium as kidney stones.....are a problem
    A few months
    Prevention of postmenopausal osteoporosis
  • Can cause nausea, dizziness, bloating and breast tenderness.