Osphena

(Ospemifene)

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Helps make sex less painful for postmenopausal women.

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Our bottom line

Osphena (Ospemifene) helps make sex less painful in postmenopausal women, but has more side-effects than topical medications applied directly to the vagina.

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    $210.92
Quick facts about Osphena
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Pill is easier to administer than topical product.
  • Most people that use Osphena (Ospemifene) tolerate it well.
  • Can be used in people who have kidney problems.
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Downsides

  • Only available as a brand name product, so it may be expensive.
  • Increases your risk of developing blood clots and stroke.
  • Increases your risk of uterine cancer.
  • If you still have your uterus, you may need to take another medicine, known as a progestin, to help keep your uterus healthy.
  • May cause you to have hot flashes or sweating, which can very bothersome for some women.
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What to expect from Osphena, on one page

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How it works

Osphena (Ospemifene) is a medicine known as a selective estrogen receptor modulator (SERM). It acts like estrogen, which relieves vaginal dryness and makes sex less painful in postmenopausal women.

Quick facts about Osphena
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Painful intercourse during menopause

Dosage forms

  • Pill
Tried Osphena? Write a review!

Prices and coupons

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What to expect when you take Osphena (Ospemifene) for Painful intercourse during menopause

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Hot flashes
  • Vaginal discharge
  • Genital discharge
  • Muscle spasms
  • Excessive sweating
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Side effect rates for Osphena (Ospemifene)

From 2200 clinical trials of Osphena when taken for painful intercourse during menopause
  • Hot flashes
    8%8%
    3%3%
  • Vaginal discharge
    4%4%
  • Muscle spasms
    3%3%
    1%1%
  • Excessive sweating
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Osphena.

Osphena (Ospemifene)
Placebo

People taking Osphena felt side effect more

People taking Osphena felt side effect less

No difference

Risks and Warnings for Osphena (Ospemifene)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. Using medicines like Osphena (Ospemifene) for more than a year can increase your risk. Talk to your doctor about other medicines you can take with Osphena (Ospemifene) to protect yourself from cancer if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Osphena (Ospemifene)

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Kidneys and liver
  • Can be used in people who have kidney problems.
Pain
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.