Protonix

(pantoprazole)

3.8/ 5 average rating with 584 reviewsforpantoprazole
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Treats heartburn and excess release of stomach acid.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

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  • Lowest price with coupon
    $402.96
Quick facts about pantoprazole
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pantoprazole)

Upsides

  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
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What to expect from pantoprazole, on one page

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People’s experience with pantoprazole

584reviews so far. What do you think?

Downsides

  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
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What to expect from pantoprazole, on one page

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How it works

Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.

Quick facts about pantoprazole
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (pantoprazole)

Used for

Dosage forms

  • Pill
  • Packet
People’s experience with pantoprazole

584reviews so far. What do you think?

Prices and coupons

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What to expect when you take Protonix (pantoprazole) for Reduces stomach acid

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Headache
  • Diarrhea
  • Nausea
  • Stomach pain
  • Vomiting
  • Gas
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Side effect rates for Protonix (pantoprazole)

From 1555 clinical trials of pantoprazole when taken for gerd
  • Headache
    12%12%
    9%9%
  • Diarrhea
    9%9%
    5%5%
  • Nausea
    7%7%
    10%10%
  • Stomach pain
    6%6%
    6%6%
  • Vomiting
    4%4%
    2%2%
  • Gas
    4%4%
    4%4%
  • Dizziness
    3%3%
    1%1%
  • Joint pain
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of pantoprazole.

Protonix (pantoprazole)
Placebo

People taking pantoprazole felt side effect more

People taking pantoprazole felt side effect less

No difference

Risks and Warnings for Protonix (pantoprazole)

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    • Higher risk if:
    • Using multiple daily doses and/or for 1 year or longer
    • People age 65 or older
    • High risk of bone fractures

    Protonix (pantoprazole) can weaken your bones and increase your risk of getting bone fractures especially in the hip, wrist, or back. The chances of this happening are higher if you take the medicine for 1 year or longer. Use Protonix (pantoprazole) at the lowest dose and for the shortest amount of time possible.

Common concerns from people taking Protonix (pantoprazole)

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Food
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Worth it
    Low hassle
    Reviewed Protonixon 10/18/2017Take it before breakfast
    68
    Woman
    A few months
    Excess stomach acid
Kidneys and liver
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
Pain
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.