Trilafon

(perphenazine)

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Treats schizophrenia.

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Our bottom line

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

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Quick facts about perphenazine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (perphenazine)

Upsides

  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
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What to expect from perphenazine, on one page

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Downsides

  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
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What to expect from perphenazine, on one page

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How it works

Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.

Quick facts about perphenazine
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (perphenazine)

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Trilafon (perphenazine) for Schizophrenia

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  • First few hoursHours
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
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  • Possible side effects
  • Drowsiness & sleepiness
  • Higher risk of infection
  • Difficulty controlling movements
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Side effect rates for Trilafon (perphenazine)

Risks and Warnings for Trilafon (perphenazine)

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    • Higher risk if:
    • People age 65 or older with dementia and psychosis

    Older people who have dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Trilafon (perphenazine). They shouldn't be given this medicine.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Trilafon (perphenazine)

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Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for perphenazine
NUnknown
Alcohol
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
Sleep
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
Weight
  • You're more likely to gain weight.