Plaquenil

(hydroxychloroquine)

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Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Plaquenil (hydroxychloroquine) is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs.

Lowest price near you
  • Price before coupon
    $226.12
  • Lowest price with coupon
    $32.71
    86% savings
Quick facts about Plaquenil
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (hydroxychloroquine)

Upsides

  • Plaquenil (hydroxychloroquine) has been shown to improve physical function in up to 80% of patients with rheumatoid arthritis. Plaquenil (hydroxychloroquine) is commonly used for lupus in children because of less side effects compared to other medications.
  • Plaquenil (hydroxychloroquine) helps minimize joint damage. It can also decrease symptoms and future complications.
  • Plaquenil (hydroxychloroquine) is a good choice for people who have difficulty tolerating newer biologic medications.
  • A generic form of Plaquenil (hydroxychloroquine) is available.
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What to expect from Plaquenil, on one page

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Downsides

  • You will likely have to take additional medications to keep your rheumatoid arthritis in control.
  • Some people may develop eye problems, so you’ll have to get your eyes checked often.
  • Depending on what you're being treated for, it can take up to 6 months for the full benefits of Plaquenil (hydroxychloroquine).
  • Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil (hydroxychloroquine).
  • If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil (hydroxychloroquine) is right for you.
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How it works

Plaquenil (hydroxychloroquine) belongs to a group of drugs called DMARDs (disease-modifying anti-rheumatic drug).It calms your immune system and blocks the functioning of parasites responsible for malaria.

Quick facts about Plaquenil
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (hydroxychloroquine)

Dosage forms

  • Pill
Tried Plaquenil? Write a review!

Prices and coupons

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What to expect when you take Plaquenil (hydroxychloroquine) for Rheumatoid arthritis

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Nausea / vomiting
  • Diarrhea
  • Stomach cramps
  • Skin problems
  • Headache
  • Vision changes
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Side effect rates for Plaquenil (hydroxychloroquine)

Risks and Warnings for Plaquenil (hydroxychloroquine)

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  • Doctors should be completely familiar with the medication label before prescribing Plaquenil (hydroxychloroquine).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Plaquenil (hydroxychloroquine)

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Interactions
  • Certain medications can interact with Plaquenil (hydroxychloroquine), so to be safe, tell your doctor about other medications and supplements you may be taking.
Alcohol
  • Don't drink alcohol while taking Plaquenil (hydroxychloroquine). Alcoholic drinks can lead to liver problems while taking Plaquenil (hydroxychloroquine).
Food
  • Take Plaquenil (hydroxychloroquine) with food or milk to help decrease nausea. Do not break or crush the pills.
  • Worth it
    Low hassle
    Reviewed PlaquenilTake Plaquenil with food Before starting medication see an optometrist for baseline assessment of your eyes.
    21
    Woman
  • Worth it
    Some hassle
    Reviewed Plaquenilon 8/26/2017Take it with food just before bed so you sleep through the worst of the side effects
    27
    Woman
    Two years or more
  • Worth it
    Big hassle
    Reviewed Plaquenilon 3/16/2017Eat with food to help prevent stomach upset
    29
    Woman
    Two years or more
    Rheumatoid arthritis
Kidneys and liver
  • If you have heart, eye, liver conditions, or psoriasis, talk to your doctor to see if Plaquenil (hydroxychloroquine) is right for you.
Pain
  • Not sure
    Reviewed hydroxychloroquineon 2/9/2018I'm not sure if it's working my pain level has increase but having more labs done next month so that will tell more
    64
    Woman
    Two years or more
    Would rather not say
  • Worth it
    Low hassle
    Reviewed Plaquenilon 5/5/2017This medicine has worked well for me however, I do have some side effects that are not as bad as the pain. Tinitis and headaches
    59
    Man
    Two years or more
    Rheumatoid arthritis