Premarin

(Conjugated Estrogens)

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3.5/ 5 average rating with 154 reviewsforPremarin
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Our bottom line

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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Quick facts about Premarin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (conjugated estrogens)

Upsides

  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
People’s experience with Premarin

154reviews so far. What do you think?

Downsides

  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
How it works

Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.

Quick facts about Premarin
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (conjugated estrogens)

Used for

  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen

Dosage forms

  • Pill
People’s experience with Premarin

154reviews so far. What do you think?

Prices and coupons

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Side effect rates for Premarin (Conjugated Estrogens)

From 658 clinical trials of Premarin when taken for estrogen replacement postmenopause (0.3 mg)
  • Headache
    13%13%
    14%14%
  • Abdominal pain
    9%9%
    6%6%
  • Breast pain
    7%7%
    8%8%
  • Nausea
    5%5%
    5%5%
  • Asthenia
    4%4%
    1%1%
  • Back pain
    4%4%
    1%1%
  • Pain
    4%4%
    4%4%
  • Flatulence
    4%4%
    2%2%
  • Insomnia
    4%4%
    4%4%
  • Leukorrhea
    4%4%
    2%2%
  • Vaginal moniliasis
    4%4%
    2%2%
  • Leg cramps
    3%3%
    1%1%
  • Depression
    3%3%
    5%5%
  • Pruritus
    3%3%
    1%1%
  • Vaginitis
    3%3%
  • Pelvic pain
    2%2%
    1%1%
  • Hypertension
    2%2%
    2%2%
  • Diarrhea
    2%2%
    2%2%
  • Dyspepsia
    2%2%
    4%4%
  • Weight gain
    2%2%
    4%4%
  • Emotional lability
    2%2%
    2%2%
  • Hypertonia
    2%2%
    1%1%
  • Acne
    2%2%
    1%1%
  • Alopecia
    2%2%
    1%1%
  • Breast enlargement
    2%2%
    1%1%
  • Breast neoplasm
    2%2%
    2%2%
  • Cervix disorder
    2%2%
  • Vaginal hemorrhage
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Premarin.

Premarin (Conjugated Estrogens)
Placebo

People taking Premarin felt side effect more

People taking Premarin felt side effect less

No difference

Risks and Warnings for Premarin (Conjugated Estrogens)

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    • Higher risk if:
    • › Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Premarin (Conjugated Estrogens) questions for

Frequently Asked Questions

This medication treats advanced prostate cancer, low estrogen levels, menopause, metastatic breast cancer, and prevents postmenopausal osteoporosis for women at significant risk of osteoporosis.

Who is this drug for?

This medication treats advanced prostate cancer, low estrogen levels, menopause, metastatic breast cancer, and prevents postmenopausal osteoporosis for women at significant risk of osteoporosis.

Common concerns from people taking Premarin (Conjugated Estrogens)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Premarin
XUnsafe
Price
  • Worth it
    Worked well
    Some hassle
    Reviewed Premarinon 10/3/2021The cost of Premarin is about 1/3 if ordered outside the US compared to the US prices.
    75
    Woman
    Two years or more
    Hot flashes and night sweats
  • Worth it
    Worked well
    Low hassle
    Reviewed Premarinon 7/7/2017The price is too high. I take it daily and have for over 20 years. Without Premarin I have severe hot flashes day and night. I also have mood swings.
    64
    Woman
    Two years or more
    Hot flashes and night sweats
Pain
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
Weight
  • Can cause nausea, dizziness, bloating and breast tenderness.