Premarin vaginal cream
(conjugated estrogens)
Relieves vaginal dryness and pain during sex due to menopause.
Our bottom line
Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Upsides
- Works locally in the vagina, so it has less side effects than estrogen pills.
- Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
- Can be dosed twice a week to relieve painful sex due to menopause.
What to expect from Premarin vaginal cream, on one page
Download Fact SheetDownsides
- Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
- Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
- Available as a branded product only, so it may be expensive.
What to expect from Premarin vaginal cream, on one page
Download Fact SheetPremarin vaginal cream (conjugated estrogens) is an estrogen hormone, which restores function lost during menopause such as vaginal dryness.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Used for
- Vaginal dryness and inflammation due to menopause
- Painful sex due to menopause
Dosage forms
- Cream
Prices and coupons
Skip prices section. Skip to what to expect section.- Get free coupon
$415.69 - Get free coupon
$416.69
What to expect when you take Premarin vaginal cream (conjugated estrogens) for Painful sex due to menopause
Skip what to expect section. Skip to side effects section.- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Effectiveness
- Full effects
- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Possible side effects
- Pelvic pain
- Vaginal discharge
- Breast pain
- Headache
- Vaginal inflammation
- Itching
Side effect rates for Premarin vaginal cream (conjugated estrogens)
- Pelvic pain3%3%
- Vaginal discharge3%3%7%7%
- Headache2%2%2%2%
- Breast pain2%2%
- Vaginal inflammation2%2%4%4%
- Other problems with the vagina or vulva2%2%3%3%
The placebo bar shows how common a side effect was for people taking a sugar pill instead of Premarin vaginal cream.
People taking Premarin vaginal cream felt side effect more
People taking Premarin vaginal cream felt side effect less
Risks and Warnings for Premarin vaginal cream (conjugated estrogens)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › Using estrogen for more than one year
- › Higher dose of estrogen
If you're taking Premarin vaginal cream (conjugated estrogens) and have your uterus, you might have a higher risk of having endometrial cancer. This risk is usually associated with using estrogen for more than 1 year. Let your doctor know if you notice any unusual bleeding. Talk to your doctor if you are worried.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Common concerns from people taking Premarin vaginal cream (conjugated estrogens)
Final section. Do you want to return to drug navigation?- Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
- Can be dosed twice a week to relieve painful sex due to menopause.