Premarin vaginal cream

(conjugated estrogens)

Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Relieves vaginal dryness and pain during sex due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Premarin vaginal cream (conjugated estrogens) has less side-effects than estrogen pills, but only works for localized symptoms of menopause.

Lowest price near you
  • Price before coupon
    $192.17
  • Lowest price with coupon
    $151.59
  • Savings
    21%
Quick facts about Premarin vaginal cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Works locally in the vagina, so it has less side effects than estrogen pills.
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Premarin vaginal cream, on one page

Download Fact Sheet
Tried Premarin vaginal cream? Write a review!

Downsides

  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms. Do not rely on these methods to protect against sexually transmitted infections for up to 72 hours after using Premarin vaginal cream (conjugated estrogens).
  • Premarin vaginal cream (conjugated estrogens) increases risk of uterine cancer so women with intact uterus should not use it by itself.
  • Available as a branded product only, so it may be expensive.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from Premarin vaginal cream, on one page

Download Fact Sheet
How it works

Premarin vaginal cream (conjugated estrogens) is an estrogen hormone, which restores function lost during menopause such as vaginal dryness.

Quick facts about Premarin vaginal cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Vaginal dryness and inflammation due to menopause
  • Painful sex due to menopause

Dosage forms

  • Cream
Tried Premarin vaginal cream? Write a review!

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 30 (0.625mg) tablets of Premarin near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Premarin vaginal cream (conjugated estrogens) for Painful sex due to menopause

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Pelvic pain
  • Vaginal discharge
  • Breast pain
  • Headache
  • Vaginal inflammation
  • Itching
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Premarin vaginal cream (conjugated estrogens)

From 208 clinical trials of Premarin vaginal cream when taken for painful sex due to menopause (0.3125 mg)
  • Pelvic pain
    3%3%
  • Vaginal discharge
    3%3%
    7%7%
  • Headache
    2%2%
    2%2%
  • Breast pain
    2%2%
  • Vaginal inflammation
    2%2%
    4%4%
  • Other problems with the vagina or vulva
    2%2%
    3%3%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Premarin vaginal cream.

Premarin vaginal cream (conjugated estrogens)
Placebo

People taking Premarin vaginal cream felt side effect more

People taking Premarin vaginal cream felt side effect less

No difference

Risks and Warnings for Premarin vaginal cream (conjugated estrogens)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Using estrogen for more than one year
    • Higher dose of estrogen

    If you're taking Premarin vaginal cream (conjugated estrogens) and have your uterus, you might have a higher risk of having endometrial cancer. This risk is usually associated with using estrogen for more than 1 year. Let your doctor know if you notice any unusual bleeding. Talk to your doctor if you are worried.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Premarin vaginal cream (conjugated estrogens)

Final section. Do you want to return to drug navigation?
Pain
  • Works better than over-the-counter lubricants to relieve pain during sex caused by menopause.
  • Can be dosed twice a week to relieve painful sex due to menopause.