Premarin Vaginal Cream

(Conjugated Estrogens)

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Relieves vaginal dryness and pain due to menopause.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

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Quick facts about Premarin Vaginal Cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
Tried Premarin Vaginal Cream? Write a review!

Downsides

  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
How it works

Premarin Vaginal Cream (Conjugated Estrogens) is a topical medication that replaces estrogen hormones in the vagina to rebuild vaginal tissue and make vaginal sex more comfortable.

Quick facts about Premarin Vaginal Cream
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Vaginal dryness and inflammation
  • Painful intercourse from menopause

Dosage forms

  • Vaginal cream, gel, or ointment
Tried Premarin Vaginal Cream? Write a review!

Prices and coupons

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Side effect rates for Premarin Vaginal Cream (Conjugated Estrogens)

From 658 clinical trials of Premarin Vaginal Cream when taken for symptoms associated with menopause (.3 mg)
  • Any side effect
    90%90%
    85%85%
  • Headache
    28%28%
    28%28%
  • Infection
    23%23%
    22%22%
  • Pain
    20%20%
    18%18%
  • Abdominal pain
    17%17%
    11%11%
  • Back pain
    13%13%
    12%12%
  • Pharyngitis
    12%12%
    11%11%
  • Dyspepsia
    11%11%
    14%14%
  • Flu syndrome
    10%10%
    11%11%
  • Rhinitis
    10%10%
    13%13%
  • Myalgia
    9%9%
    8%8%
  • Upper respiratory infection
    9%9%
    11%11%
  • Asthenia
    8%8%
    5%5%
  • Arthralgia
    7%7%
    12%12%
  • Insomnia
    7%7%
    10%10%
  • Sinusitis
    7%7%
    7%7%
  • Breast pain
    7%7%
    9%9%
  • Accidental injury
    6%6%
    9%9%
  • Diarrhea
    6%6%
    6%6%
  • Flatulence
    6%6%
    3%3%
  • Nausea
    6%6%
    9%9%
  • Depression
    5%5%
    7%7%
  • Pruritus
    5%5%
    2%2%
  • Vaginal moniliasis
    5%5%
    2%2%
  • Vaginitis
    5%5%
    1%1%
  • Dizziness
    4%4%
    5%5%
  • Cough increased
    4%4%
    4%4%
  • Leukorrhea
    4%4%
    3%3%
  • Leg cramps
    3%3%
    2%2%
  • Nervousness
    2%2%
    2%2%
  • Vaginal hemorrhage
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Premarin Vaginal Cream.

Premarin Vaginal Cream (Conjugated Estrogens)
Placebo

People taking Premarin Vaginal Cream felt side effect more

People taking Premarin Vaginal Cream felt side effect less

No difference

Risks and Warnings for Premarin Vaginal Cream (Conjugated Estrogens)

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    • Higher risk if:
    • › Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Premarin Vaginal Cream (Conjugated Estrogens)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Premarin Vaginal Cream
XUnsafe
Pain
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.