Crinone

(Progesterone Vaginal Gel)

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Regulates your menstrual cycle and supports fertility treatments.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Crinone (Progesterone Vaginal Gel) is a long-acting vaginal gel used in fertility treatments, and you don't have to apply it as often as progesterone vaginal inserts.

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Quick facts about Progesterone Vaginal Gel
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Crinone (Progesterone Vaginal Gel) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg. If you become pregnant, Crinone (Progesterone Vaginal Gel) can be used for another 10 to 12 weeks until your progesterone levels are high enough.
  • Women can also use Crinone (Progesterone Vaginal Gel) to treat secondary amenorrhea (the absence of menstrual cycles in women who used to have a regular period) due to a decrease in the hormone progesterone. Crinone (Progesterone Vaginal Gel) is used to bring the hormone levels back up to normal.
Tried Progesterone Vaginal Gel? Write a review!

Downsides

  • Crinone (Progesterone Vaginal Gel) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Crinone (Progesterone Vaginal Gel) can cause a white vaginal discharge a few days after taking the medicine, so wearing a panty liner can make you feel more comfortable.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone (Progesterone Vaginal Gel).
How it works

Crinone (Progesterone Vaginal Gel) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.

Quick facts about Progesterone Vaginal Gel
  • Drug class: Women's health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

  • Female infertility
  • Amenorrhea

Dosage forms

  • Vaginal cream, gel, or ointment
Tried Progesterone Vaginal Gel? Write a review!

Prices and coupons

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Side effect rates for Crinone (Progesterone Vaginal Gel)

From 62 clinical trials of Progesterone Vaginal Gel when taken for amenorrhea (4% gel)
  • Emotional Lability
    23%23%
  • Fatigue
    21%21%
  • Cramps NOS
    19%19%
  • Headache
    19%19%
  • Depression
    19%19%
  • Sleep Disorder
    18%18%
  • Bloating
    13%13%
  • Vaginal Discharge
    11%11%
  • Nausea
    8%8%
  • Back Pain
    8%8%
  • Myalgia
    8%8%
  • Abdominal Pain
    5%5%
  • Appetite Increased
    5%5%
  • Upper Respiratory Tract Infection
    5%5%
  • Pruitis genital
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Progesterone Vaginal Gel.

Crinone (Progesterone Vaginal Gel)
Placebo

People taking Progesterone Vaginal Gel felt side effect more

People taking Progesterone Vaginal Gel felt side effect less

No difference

Risks and Warnings for Crinone (Progesterone Vaginal Gel)

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    • Higher risk if:
    • › Personal or family history of breast cancer

    It is not completely clear if progestin, like as Crinone (Progesterone Vaginal Gel), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Common concerns from people taking Crinone (Progesterone Vaginal Gel)

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Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Progesterone Vaginal Gel
NUnknown
Weight
  • Crinone (Progesterone Vaginal Gel) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.