Endometrin
(progesterone vaginal insert)
Supports other fertility treatments.
Our bottom line
Endometrin (progesterone vaginal insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Upsides
- Helps increase your chances of getting pregnant.
- Exposes your body to less hormone compared to progesterone pills or injections.
- Endometrin (progesterone vaginal insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
- Endometrin (progesterone vaginal insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that must be inserted lying down, Endometrin (progesterone vaginal insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
What to expect from Endometrin, on one page
Download Fact Sheet
55Downsides
- Endometrin (progesterone vaginal insert) can cause vaginal irritation and burning.
- Inserting the applicator can possibly cause discomfort or infection.
- Endometrin (progesterone vaginal insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
- You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Endometrin (progesterone vaginal insert).
- Only available as brand name, so it may be expensive.
What to expect from Endometrin, on one page
Download Fact SheetEndometrin (progesterone vaginal insert) contains progesterone, an essential hormone for pregnancy. Progesterone prepares the uterus to receive and nourish a fertilized egg.
- Drug class: Women's health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Used for
Dosage forms
- Vaginal insert
Prices and coupons
Skip prices section. Skip to what to expect section.
Pay as low as$282.51Retail priceRetail priceLearn more- CostcoGet free coupon$281.48
- Kroger PharmacyGet free coupon$285.11
- Get free coupon
$285.11
What to expect when you take Endometrin (progesterone vaginal insert) for Female infertility
Skip what to expect section. Skip to side effects section.- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Effectiveness
- Starts to kick inFull effects
- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Possible side effects
- Pain after egg harvesting
- Stomach pain
- Nausea
- Overstimulation of ovaries
- Headache
- Vomiting
Side effect rates for Endometrin (progesterone vaginal insert)
- Pain after egg harvesting25%25%
- Stomach pain12%12%
- Nausea7%7%
- Overstimulation of ovaries7%7%
- Stomach bloating and swelling4%4%
- Constipation3%3%
- Fatigue3%3%
- Headache3%3%
- Uterine spasm3%3%
- Vaginal bleeding3%3%
- Vomiting2%2%
The placebo bar shows how common a side effect was for people taking a sugar pill instead of Endometrin.
People taking Endometrin felt side effect more
People taking Endometrin felt side effect less
Risks and Warnings for Endometrin (progesterone vaginal insert)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › History of heart disease
- › History of blood clots
Endometrin (progesterone vaginal insert) should not be taken if you've had a heart attack, have heart disease, or have blood clots, since the medicine can make it worse. Tell your doctor before starting this medicine if you have a personal history of heart problems or blood clots. Go to the emergency room right away if you notice chest pain, difficulty breathing, or extreme pain in any of your limbs.